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In silico modeling of the Menkes copper-translocating P-type ATPase 3rd metal binding domain predicts that phosphorylation regulates copper-binding.
Veldhuis NA, Kuiper MJ, Dobson RC, Pearson RB, Camakaris J. Veldhuis NA, et al. Among authors: dobson rc. Biometals. 2011 Jun;24(3):477-87. doi: 10.1007/s10534-011-9410-0. Epub 2011 Jan 22. Biometals. 2011. PMID: 21258844
Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues.
Boughton BA, Griffin MD, O'Donnell PA, Dobson RC, Perugini MA, Gerrard JA, Hutton CA. Boughton BA, et al. Among authors: dobson rc. Bioorg Med Chem. 2008 Dec 1;16(23):9975-83. doi: 10.1016/j.bmc.2008.10.026. Epub 2008 Oct 17. Bioorg Med Chem. 2008. PMID: 18977662
Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis.
Dobson RC, Perugini MA, Jameson GB, Gerrard JA. Dobson RC, et al. Biochimie. 2009 Aug;91(8):1036-44. doi: 10.1016/j.biochi.2009.05.013. Epub 2009 Jun 6. Biochimie. 2009. PMID: 19505526
Exploring the dihydrodipicolinate synthase tetramer: how resilient is the dimer-dimer interface?
Griffin MD, Dobson RC, Gerrard JA, Perugini MA. Griffin MD, et al. Among authors: dobson rc. Arch Biochem Biophys. 2010 Feb 1;494(1):58-63. doi: 10.1016/j.abb.2009.11.014. Epub 2009 Nov 15. Arch Biochem Biophys. 2010. PMID: 19919824
Crystallization and preliminary X-ray diffraction analysis of diaminopimelate epimerase from Escherichia coli.
Hor L, Dobson RC, Dogovski C, Hutton CA, Perugini MA. Hor L, et al. Among authors: dobson rc. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):37-40. doi: 10.1107/S1744309109047708. Epub 2009 Dec 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20057066 Free PMC article.
The crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: unambiguous resolution of the stereochemistry of the condensation product.
Boughton BA, Dobson RC, Hutton CA. Boughton BA, et al. Among authors: dobson rc. Proteins. 2012 Aug;80(8):2117-22. doi: 10.1002/prot.24106. Epub 2012 Jun 4. Proteins. 2012. PMID: 22552955
Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition.
Atkinson SC, Dogovski C, Downton MT, Czabotar PE, Dobson RC, Gerrard JA, Wagner J, Perugini MA. Atkinson SC, et al. Among authors: dobson rc. Plant Mol Biol. 2013 Mar;81(4-5):431-46. doi: 10.1007/s11103-013-0014-7. Epub 2013 Jan 26. Plant Mol Biol. 2013. PMID: 23354837
Dimerization of bacterial diaminopimelate epimerase is essential for catalysis.
Hor L, Dobson RC, Downton MT, Wagner J, Hutton CA, Perugini MA. Hor L, et al. Among authors: dobson rc. J Biol Chem. 2013 Mar 29;288(13):9238-48. doi: 10.1074/jbc.M113.450148. Epub 2013 Feb 19. J Biol Chem. 2013. PMID: 23426375 Free PMC article.
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS. Murphy JM, et al. Among authors: dobson rc. Immunity. 2013 Sep 19;39(3):443-53. doi: 10.1016/j.immuni.2013.06.018. Epub 2013 Sep 5. Immunity. 2013. PMID: 24012422
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.
Hildebrand JM, Tanzer MC, Lucet IS, Young SN, Spall SK, Sharma P, Pierotti C, Garnier JM, Dobson RC, Webb AI, Tripaydonis A, Babon JJ, Mulcair MD, Scanlon MJ, Alexander WS, Wilks AF, Czabotar PE, Lessene G, Murphy JM, Silke J. Hildebrand JM, et al. Among authors: dobson rc. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7. doi: 10.1073/pnas.1408987111. Epub 2014 Oct 6. Proc Natl Acad Sci U S A. 2014. PMID: 25288762 Free PMC article.
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