Dobson RC - Search Results

1

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the grapevine Vitis vinifera.

Atkinson SC, Dogovski C, Newman J, Dobson RC, Perugini MA. Atkinson SC, et al. Among authors: dobson rc. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1537-41. doi: 10.1107/S1744309111038395. Epub 2011 Nov 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 22139160 Free PMC article.

2

Dihydrodipicolinate synthase is not inhibited by its substrate, (S)-aspartate beta-semialdehyde.

Dobson RC, Gerrard JA, Pearce FG. Dobson RC, et al. Biochem J. 2004 Feb 1;377(Pt 3):757-62. doi: 10.1042/BJ20031389. Biochem J. 2004. PMID: 14580236 Free PMC article.

3

The crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: further evidence for a catalytic triad.

Dobson RC, Valegård K, Gerrard JA. Dobson RC, et al. J Mol Biol. 2004 Apr 23;338(2):329-39. doi: 10.1016/j.jmb.2004.02.060. J Mol Biol. 2004. PMID: 15066435

4

Dihydrodipicolinate synthase (DHDPS) from Escherichia coli displays partial mixed inhibition with respect to its first substrate, pyruvate.

Dobson RC, Griffin MD, Roberts SJ, Gerrard JA. Dobson RC, et al. Biochimie. 2004 Apr-May;86(4-5):311-5. doi: 10.1016/j.biochi.2004.03.008. Biochimie. 2004. PMID: 15194235

5

Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate.

Turner JJ, Healy JP, Dobson RC, Gerrard JA, Hutton CA. Turner JJ, et al. Among authors: dobson rc. Bioorg Med Chem Lett. 2005 Feb 15;15(4):995-8. doi: 10.1016/j.bmcl.2004.12.043. Bioorg Med Chem Lett. 2005. PMID: 15686899

6

The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance.

Dobson RC, Griffin MD, Jameson GB, Gerrard JA. Dobson RC, et al. Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1116-24. doi: 10.1107/S0907444905016318. Epub 2005 Jul 20. Acta Crystallogr D Biol Crystallogr. 2005. PMID: 16041077

7

Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase.

Dobson RC, Devenish SR, Turner LA, Clifford VR, Pearce FG, Jameson GB, Gerrard JA. Dobson RC, et al. Biochemistry. 2005 Oct 4;44(39):13007-13. doi: 10.1021/bi051281w. Biochemistry. 2005. PMID: 16185069

8

Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?

Mitsakos V, Dobson RC, Pearce FG, Devenish SR, Evans GL, Burgess BR, Perugini MA, Gerrard JA, Hutton CA. Mitsakos V, et al. Among authors: dobson rc. Bioorg Med Chem Lett. 2008 Jan 15;18(2):842-4. doi: 10.1016/j.bmcl.2007.11.026. Epub 2007 Nov 13. Bioorg Med Chem Lett. 2008. PMID: 18054225

9

Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.

Kefala G, Evans GL, Griffin MD, Devenish SR, Pearce FG, Perugini MA, Gerrard JA, Weiss MS, Dobson RC. Kefala G, et al. Among authors: dobson rc. Biochem J. 2008 Apr 15;411(2):351-60. doi: 10.1042/BJ20071360. Biochem J. 2008. PMID: 18062777

10

Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase.

Boughton BA, Dobson RC, Gerrard JA, Hutton CA. Boughton BA, et al. Among authors: dobson rc. Bioorg Med Chem Lett. 2008 Jan 15;18(2):460-3. doi: 10.1016/j.bmcl.2007.11.108. Epub 2007 Dec 3. Bioorg Med Chem Lett. 2008. PMID: 18077163

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