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Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate.
Ved HS, Koenig ML, Dave JR, Doctor BP. Ved HS, et al. Among authors: doctor bp. Neuroreport. 1997 Mar 3;8(4):963-8. doi: 10.1097/00001756-199703030-00029. Neuroreport. 1997. PMID: 9141073
Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A.
Rajendran V, Prakash KR, Ved HS, Saxena A, Doctor BP, Kozikowski AP. Rajendran V, et al. Among authors: doctor bp. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2467-9. doi: 10.1016/s0960-894x(00)00494-7. Bioorg Med Chem Lett. 2000. PMID: 11078202
Complete amino acid sequence of fetal bovine serum acetylcholinesterase and its comparison in various regions with other cholinesterases.
Doctor BP, Chapman TC, Christner CE, Deal CD, De La Hoz DM, Gentry MK, Ogert RA, Rush RS, Smyth KK, Wolfe AD. Doctor BP, et al. FEBS Lett. 1990 Jun 18;266(1-2):123-7. doi: 10.1016/0014-5793(90)81522-p. FEBS Lett. 1990. PMID: 2365060
Structure of glycan moieties responsible for the extended circulatory life time of fetal bovine serum acetylcholinesterase and equine serum butyrylcholinesterase.
Saxena A, Raveh L, Ashani Y, Doctor BP. Saxena A, et al. Among authors: doctor bp. Biochemistry. 1997 Jun 17;36(24):7481-9. doi: 10.1021/bi963156d. Biochemistry. 1997. PMID: 9200697
[+]-Huperzine A protects against soman toxicity in guinea pigs.
Wang Y, Wei Y, Oguntayo S, Jensen N, Doctor BP, Nambiar MP. Wang Y, et al. Among authors: doctor bp. Neurochem Res. 2011 Dec;36(12):2381-90. doi: 10.1007/s11064-011-0564-5. Epub 2011 Aug 7. Neurochem Res. 2011. PMID: 21822920
Systemic administration of the potential countermeasure huperzine reversibly inhibits central and peripheral acetylcholinesterase activity without adverse cognitive-behavioral effects.
Myers TM, Sun W, Saxena A, Doctor BP, Bonvillain AJ, Clark MG. Myers TM, et al. Among authors: doctor bp. Pharmacol Biochem Behav. 2010 Jan;94(3):477-81. doi: 10.1016/j.pbb.2009.10.011. Epub 2009 Nov 11. Pharmacol Biochem Behav. 2010. PMID: 19909771
An ex vivo approach for the evaluation of reversible inhibitors as potential pretreatments against organophosphate toxicity.
Tonduli LS, Doctor BP, Saxena A. Tonduli LS, et al. Among authors: doctor bp. Chem Biol Interact. 2005 Dec 15;157-158:426-7. doi: 10.1016/j.cbi.2005.10.089. Chem Biol Interact. 2005. PMID: 16429574
Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman.
Gordon RK, Haigh JR, Garcia GE, Feaster SR, Riel MA, Lenz DE, Aisen PS, Doctor BP. Gordon RK, et al. Among authors: doctor bp. Chem Biol Interact. 2005 Dec 15;157-158:239-46. doi: 10.1016/j.cbi.2005.10.031. Epub 2005 Oct 26. Chem Biol Interact. 2005. PMID: 16256090
Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure.
Curtin BF, Tetz LM, Compton JR, Doctor BP, Gordon RK, Nambiar MP. Curtin BF, et al. Among authors: doctor bp. J Cell Biochem. 2005 Nov 1;96(4):839-49. doi: 10.1002/jcb.20591. J Cell Biochem. 2005. PMID: 16149071
Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B.
Rajendran V, Saxena A, Doctor BP, Kozikowski AP. Rajendran V, et al. Among authors: doctor bp. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1521-3. doi: 10.1016/s0960-894x(02)00204-4. Bioorg Med Chem Lett. 2002. PMID: 12031333
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