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The sensitizing capacity of the antioxidants propyl, octyl, and dodecyl gallate and some related gallic acid esters.
Hausen BM, Beyer W. Hausen BM, et al. Contact Dermatitis. 1992 Apr;26(4):253-8. doi: 10.1111/j.1600-0536.1992.tb00238.x. Contact Dermatitis. 1992. PMID: 1395563 Review.
8 alkyl gallates, including the widely used antioxidants propyl, octyl, and dodecyl (= lauryl) gallate, have been subjected to experimental sensitization in guinea pigs. Using a modern sensitization procedure, the results showed that all gallates are moderate to str …
8 alkyl gallates, including the widely used antioxidants propyl, octyl, and dodecyl (= lauryl) gallate, have been subjected to …
Antioxidant activity of dodecyl gallate.
Kubo I, Masuoka N, Xiao P, Haraguchi H. Kubo I, et al. J Agric Food Chem. 2002 Jun 5;50(12):3533-9. doi: 10.1021/jf011250h. J Agric Food Chem. 2002. PMID: 12033824
The inhibition kinetics analyzed by Lineweaver-Burk plots found that dodecylgallate is a noncompetitive inhibitor for the generation of superoxide anion. Dodecyl gallate also inhibits formation of uric acid. The inhibition kinetics analyzed by Lineweaver-Burk plots …
The inhibition kinetics analyzed by Lineweaver-Burk plots found that dodecylgallate is a noncompetitive inhibitor for the generation of supe …
Dodecyl gallate induces apoptosis by upregulating the caspase-dependent apoptotic pathway and inhibiting the expression of anti-apoptotic Bcl-2 family proteins in human osteosarcoma cells.
Cheng CH, Cheng YP, Chang IL, Chen HY, Wu CC, Hsieh CP. Cheng CH, et al. Mol Med Rep. 2016 Feb;13(2):1495-500. doi: 10.3892/mmr.2015.4717. Epub 2015 Dec 24. Mol Med Rep. 2016. PMID: 26707422 Free PMC article.
Dodecyl gallate (DG) is a gallic acid ester that has been shown to inhibit tumor growth. ...
Dodecyl gallate (DG) is a gallic acid ester that has been shown to inhibit tumor growth. ...
Dodecyl gallate, permitted in food, is a strong sensitizer.
van der Meeren HL. van der Meeren HL. Contact Dermatitis. 1987 May;16(5):260-2. doi: 10.1111/j.1600-0536.1987.tb01449.x. Contact Dermatitis. 1987. PMID: 2957151
We found contact allergy in 4 of 10 workers having only limited contact with dodecyl gallate in the very low concentration of 0.05%. It is important to recognize its strong sensitizing capacity. Workers working with dodecyl gallate should avoid direct …
We found contact allergy in 4 of 10 workers having only limited contact with dodecyl gallate in the very low concentration of …
Antifungal activity of octyl gallate.
Fujita K, Kubo I. Fujita K, et al. Int J Food Microbiol. 2002 Dec 15;79(3):193-201. doi: 10.1016/s0168-1605(02)00108-3. Int J Food Microbiol. 2002. PMID: 12371654
Octyl gallate at 100 microg /ml reduced plasma membrane fluidity to 48% of control. On the other hand, dodecyl gallate at the same concentration reduced it to 76% of control. Only octyl gallate inhibited glucose-induced medium acidification, indicating direct or ind …
Octyl gallate at 100 microg /ml reduced plasma membrane fluidity to 48% of control. On the other hand, dodecyl gallate at the …
Non-antibiotic antibacterial activity of dodecyl gallate.
Kubo I, Fujita Ki, Nihei Ki, Masuoka N. Kubo I, et al. Bioorg Med Chem. 2003 Feb 20;11(4):573-80. doi: 10.1016/s0968-0896(02)00436-4. Bioorg Med Chem. 2003. PMID: 12538022
The time-kill curve study indicates that this amphipathic gallate exhibits bactericidal activity against methicillin resistant Staphylococcus aureus (MRSA) strains. Dodecyl (lauryl) gallate inhibited oxygen consumption in whole cells and oxidation of NADH in membran …
The time-kill curve study indicates that this amphipathic gallate exhibits bactericidal activity against methicillin resistant Staphylococcu …
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity.
Singulani JL, Scorzoni L, Lourencetti NMS, Oliveira LR, Conçolaro RS, da Silva PB, Nazaré AC, Polaquini CR, Victorelli FD, Chorilli M, Regasini LO, Fusco Almeida AM, Mendes Giannini MJS. Singulani JL, et al. Int J Pharm. 2018 Aug 25;547(1-2):630-636. doi: 10.1016/j.ijpharm.2018.06.013. Epub 2018 Jun 6. Int J Pharm. 2018. PMID: 29883792
In this work, the antifungal efficacy and toxicity of dodecyl gallate (DOD) associated with a NLS was evaluated through in vitro and in vivo tests. ...
In this work, the antifungal efficacy and toxicity of dodecyl gallate (DOD) associated with a NLS was evaluated through in vit …
Toxicology of gallates: a review and evaluation.
van der Heijden CA, Janssen PJ, Strik JJ. van der Heijden CA, et al. Food Chem Toxicol. 1986 Oct-Nov;24(10-11):1067-70. doi: 10.1016/0278-6915(86)90290-5. Food Chem Toxicol. 1986. PMID: 3542759 Review.
Mutagenicity studies with octyl gallate and dodecyl gallate are lacking. The biokinetics of propyl gallate apparently differ from those of octyl and dodecyl gallate, the octyl and dodecyl esters being absorbed and hydrolysed to a lesser degree than the …
Mutagenicity studies with octyl gallate and dodecyl gallate are lacking. The biokinetics of propyl gallate apparently differ f …
Lauryl gallate induces apoptosis via p38-MAPK phosphorylation and autophagy in chemoresistant human lung cancer cells.
Huang YH, Cherng SH, Chiu LY, Hsu KH, Tseng JS, Lee PH, Sheu GT, Yang TY. Huang YH, et al. Arch Biochem Biophys. 2025 Dec;774:110633. doi: 10.1016/j.abb.2025.110633. Epub 2025 Oct 6. Arch Biochem Biophys. 2025. PMID: 41062049 Free article.
Docetaxel (DOC) and vincristine (VCR) have been widely used in cancer chemotherapy but their efficacy is restricted by P-glycoprotein (P-gp) overexpression. Lauryl gallate (LG) is a plant-derived small molecule which acts as antioxidant in normal cells. ...
Docetaxel (DOC) and vincristine (VCR) have been widely used in cancer chemotherapy but their efficacy is restricted by P-glycoprotein (P-gp) …
Lauryl gallate promotes platelet activation and thrombus formation: a promising application to stop bleeding.
Hadjkacem B, Garcia C, Series J, Pons V, Mahmoudi A, Gales C, Voisin S, Ribes A, Gratacap MP, Gargouri A, Payrastre B. Hadjkacem B, et al. Clin Sci (Lond). 2025 Dec 18;139(24):1643-57. doi: 10.1042/CS20257213. Clin Sci (Lond). 2025. PMID: 41410596 Free PMC article.
Lauryl gallate (LG, E312) is an antioxidant with hydrophobic properties that contribute to its activity by increasing affinity for membranes and acting on the lipid phase transition and likely the lateral membrane organization. ...
Lauryl gallate (LG, E312) is an antioxidant with hydrophobic properties that contribute to its activity by increasing affinity …
152 results