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Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats.
Allred CD, Allred KF, Ju YH, Clausen LM, Doerge DR, Schantz SL, Korol DL, Wallig MA, Helferich WG. Allred CD, et al. Carcinogenesis. 2004 Feb;25(2):211-8. doi: 10.1093/carcin/bgg198. Epub 2003 Oct 24. Carcinogenesis. 2004. PMID: 14578162
Acute and chronic effects of oral genistein administration in neonatal mice.
Cimafranca MA, Davila J, Ekman GC, Andrews RN, Neese SL, Peretz J, Woodling KA, Helferich WG, Sarkar J, Flaws JA, Schantz SL, Doerge DR, Cooke PS. Cimafranca MA, et al. Biol Reprod. 2010 Jul;83(1):114-21. doi: 10.1095/biolreprod.109.080549. Epub 2010 Mar 31. Biol Reprod. 2010. PMID: 20357267 Free PMC article.
Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice.
Liu Y, Hilakivi-Clarke L, Zhang Y, Wang X, Pan YX, Xuan J, Fleck SC, Doerge DR, Helferich WG. Liu Y, et al. Mol Nutr Food Res. 2015 Aug;59(8):1419-30. doi: 10.1002/mnfr.201500028. Epub 2015 Jun 26. Mol Nutr Food Res. 2015. PMID: 25820259 Free PMC article.
Lifetime Genistein Intake Increases the Response of Mammary Tumors to Tamoxifen in Rats.
Zhang X, Cook KL, Warri A, Cruz IM, Rosim M, Riskin J, Helferich W, Doerge D, Clarke R, Hilakivi-Clarke L. Zhang X, et al. Clin Cancer Res. 2017 Feb 1;23(3):814-824. doi: 10.1158/1078-0432.CCR-16-1735. Clin Cancer Res. 2017. PMID: 28148690 Free PMC article.
Using dietary exposure and physiologically based pharmacokinetic/pharmacodynamic modeling in human risk extrapolations for acrylamide toxicity.
Doerge DR, Young JF, Chen JJ, Dinovi MJ, Henry SH. Doerge DR, et al. J Agric Food Chem. 2008 Aug 13;56(15):6031-8. doi: 10.1021/jf073042g. Epub 2008 Jul 15. J Agric Food Chem. 2008. PMID: 18624435 Review.
Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover).
Roberts DW, Doerge DR, Churchwell MI, Gamboa da Costa G, Marques MM, Tolleson WH. Roberts DW, et al. J Agric Food Chem. 2004 Oct 20;52(21):6623-32. doi: 10.1021/jf049418x. J Agric Food Chem. 2004. PMID: 15479032
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