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126 results
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Endothelin: a new challenge.
Doherty AM. Doherty AM. J Med Chem. 1992 May 1;35(9):1493-508. doi: 10.1021/jm00087a001. J Med Chem. 1992. PMID: 1315867 Review. No abstract available.
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
Barrett SD, Bridges AJ, Dudley DT, Saltiel AR, Fergus JH, Flamme CM, Delaney AM, Kaufman M, LePage S, Leopold WR, Przybranowski SA, Sebolt-Leopold J, Van Becelaere K, Doherty AM, Kennedy RM, Marston D, Howard WA Jr, Smith Y, Warmus JS, Tecle H. Barrett SD, et al. Among authors: doherty am. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6501-4. doi: 10.1016/j.bmcl.2008.10.054. Epub 2008 Oct 15. Bioorg Med Chem Lett. 2008. PMID: 18952427
Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors.
Burnouf C, Auclair E, Avenel N, Bertin B, Bigot C, Calvet A, Chan K, Durand C, Fasquelle V, Féru F, Gilbertsen R, Jacobelli H, Kebsi A, Lallier E, Maignel J, Martin B, Milano S, Ouagued M, Pascal Y, Pruniaux MP, Puaud J, Rocher MN, Terrasse C, Wrigglesworth R, Doherty AM. Burnouf C, et al. Among authors: doherty am. J Med Chem. 2000 Dec 14;43(25):4850-67. doi: 10.1021/jm000315p. J Med Chem. 2000. PMID: 11123995
Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 modifications.
Plummer JS, Berryman KA, Cai C, Cody WL, DiMaio J, Doherty AM, Edmunds JJ, He JX, Holland DR, Levesque S, Kent DR, Narasimhan LS, Rubin JR, Rapundalo ST, Siddiqui MA, Susser AJ, St-Denis Y, Winocour PD. Plummer JS, et al. Among authors: doherty am. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3409-14. doi: 10.1016/s0960-894x(98)00613-1. Bioorg Med Chem Lett. 1998. PMID: 9873743
Butenolide endothelin antagonists with improved aqueous solubility.
Patt WC, Cheng XM, Repine JT, Lee C, Reisdorph BR, Massa MA, Doherty AM, Welch KM, Bryant JW, Flynn MA, Walker DM, Schroeder RL, Haleen SJ, Keiser JA. Patt WC, et al. Among authors: doherty am. J Med Chem. 1999 Jun 17;42(12):2162-8. doi: 10.1021/jm980504w. J Med Chem. 1999. PMID: 10377221
Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity.
Schroeder MC, Hamby JM, Connolly CJ, Grohar PJ, Winters RT, Barvian MR, Moore CW, Boushelle SL, Crean SM, Kraker AJ, Driscoll DL, Vincent PW, Elliott WL, Lu GH, Batley BL, Dahring TK, Major TC, Panek RL, Doherty AM, Showalter HD. Schroeder MC, et al. Among authors: doherty am. J Med Chem. 2001 Jun 7;44(12):1915-26. doi: 10.1021/jm0004291. J Med Chem. 2001. PMID: 11384237
Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1' modifications.
Plummer JS, Berryman KA, Cai C, Cody WL, DiMaio J, Doherty AM, Eaton S, Edmunds JJ, Holland DR, Lafleur D, Levesque S, Narasimhan LS, Rubin JR, Rapundalo ST, Siddiqui MA, Susser A, St-Denis Y, Winocour P. Plummer JS, et al. Among authors: doherty am. Bioorg Med Chem Lett. 1999 Mar 22;9(6):835-40. doi: 10.1016/s0960-894x(99)00096-7. Bioorg Med Chem Lett. 1999. PMID: 10206546
Synthesis and tyrosine kinase inhibitory activity of a series of 2-amino-8H-pyrido[2,3-d]pyrimidines: identification of potent, selective platelet-derived growth factor receptor tyrosine kinase inhibitors.
Boschelli DH, Wu Z, Klutchko SR, Showalter HD, Hamby JM, Lu GH, Major TC, Dahring TK, Batley B, Panek RL, Keiser J, Hartl BG, Kraker AJ, Klohs WD, Roberts BJ, Patmore S, Elliott WL, Steinkampf R, Bradford LA, Hallak H, Doherty AM. Boschelli DH, et al. Among authors: doherty am. J Med Chem. 1998 Oct 22;41(22):4365-77. doi: 10.1021/jm980398y. J Med Chem. 1998. PMID: 9784112
126 results