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Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity.
Doi M, Yamaoka I, Nakayama M, Mochizuki S, Sugahara K, Yoshizawa F. Doi M, et al. J Nutr. 2005 Sep;135(9):2103-8. doi: 10.1093/jn/135.9.2103. J Nutr. 2005. PMID: 16140883
Isoleucine, a potent plasma glucose-lowering amino acid, stimulates glucose uptake in C2C12 myotubes.
Doi M, Yamaoka I, Fukunaga T, Nakayama M. Doi M, et al. Biochem Biophys Res Commun. 2003 Dec 26;312(4):1111-7. doi: 10.1016/j.bbrc.2003.11.039. Biochem Biophys Res Commun. 2003. PMID: 14651987
Lipoprotein lipase activator NO-1886 (ibrolipim) accelerates the mRNA expression of fatty acid oxidation-related enzymes in rat liver.
Doi M, Kondo Y, Tsutsumi K. Doi M, et al. Metabolism. 2003 Dec;52(12):1547-50. doi: 10.1016/j.metabol.2003.07.007. Metabolism. 2003. PMID: 14669153
Intravenous administration of amino acids during anesthesia stimulates muscle protein synthesis and heat accumulation in the body.
Yamaoka I, Doi M, Nakayama M, Ozeki A, Mochizuki S, Sugahara K, Yoshizawa F. Yamaoka I, et al. Among authors: doi m. Am J Physiol Endocrinol Metab. 2006 May;290(5):E882-8. doi: 10.1152/ajpendo.00333.2005. Epub 2005 Dec 13. Am J Physiol Endocrinol Metab. 2006. PMID: 16352675
NO-1886 (ibrolipim), a lipoprotein lipase-promoting agent, accelerates the expression of UCP3 messenger RNA and ameliorates obesity in ovariectomized rats.
Kano S, Doi M. Kano S, et al. Among authors: doi m. Metabolism. 2006 Feb;55(2):151-8. doi: 10.1016/j.metabol.2005.08.007. Metabolism. 2006. PMID: 16423620
Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis.
Doi M, Yamaoka I, Nakayama M, Sugahara K, Yoshizawa F. Doi M, et al. Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1683-93. doi: 10.1152/ajpendo.00609.2006. Epub 2007 Feb 13. Am J Physiol Endocrinol Metab. 2007. PMID: 17299083
Glucose infusion suppresses surgery-induced muscle protein breakdown by inhibiting ubiquitin-proteasome pathway in rats.
Mikura M, Yamaoka I, Doi M, Kawano Y, Nakayama M, Nakao R, Hirasaka K, Okumura Y, Nikawa T. Mikura M, et al. Among authors: doi m. Anesthesiology. 2009 Jan;110(1):81-8. doi: 10.1097/ALN.0b013e318190b6c1. Anesthesiology. 2009. PMID: 19104174
Furthermore, muscular mRNA expression of proteolytic-related genes (atrogin-1/MAFbx, muscle ring finger-1, mu- and m-calpain, and cathepsin L and H) and phosphorylation of components of insulin signaling (forkhead box O3 and protein kinase B) were evaluated. ...
Furthermore, muscular mRNA expression of proteolytic-related genes (atrogin-1/MAFbx, muscle ring finger-1, mu- and m-calpain, and cat …
Enhancement of myofibrillar proteolysis following infusion of amino acid mixture correlates positively with elevation of core body temperature in rats.
Yamaoka I, Mikura M, Nishimura M, Doi M, Kawano Y, Nakayama M. Yamaoka I, et al. Among authors: doi m. J Nutr Sci Vitaminol (Tokyo). 2008 Dec;54(6):467-74. doi: 10.3177/jnsv.54.467. J Nutr Sci Vitaminol (Tokyo). 2008. PMID: 19155585
Insulin mediates the linkage acceleration of muscle protein synthesis, thermogenesis, and heat storage by amino acids.
Yamaoka I, Doi M, Kawano Y, Nakayama M, Watanabe Y, Oba K, Sugahara K, Yoshizawa F. Yamaoka I, et al. Among authors: doi m. Biochem Biophys Res Commun. 2009 Aug 14;386(1):252-6. doi: 10.1016/j.bbrc.2009.06.031. Epub 2009 Jun 10. Biochem Biophys Res Commun. 2009. PMID: 19523452
Circadian changes in core body temperature, metabolic rate and locomotor activity in rats on a high-protein, carbohydrate-free diet.
Yamaoka I, Hagi M, Doi M. Yamaoka I, et al. Among authors: doi m. J Nutr Sci Vitaminol (Tokyo). 2009 Dec;55(6):511-7. doi: 10.3177/jnsv.55.511. J Nutr Sci Vitaminol (Tokyo). 2009. PMID: 20086322
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