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Page 1
Structural insights into MERS and SARS coronavirus membrane proteins.
Mann MK, Yin Y, Marsili S, Xie J, Doijen J, Miller R, Piassek M, van den Broeck N, Kariuki CK, de Gruyter HLM, Leijs AA, Snijder EJ, van Hemert MJ, Keustermans K, Van Gool M, Yu X, Loock MV, Koul A, Sharma S, Van Damme E, Abeywickrema P. Mann MK, et al. Among authors: doijen j. Commun Biol. 2025 Nov 24;8(1):1651. doi: 10.1038/s42003-025-09042-3. Commun Biol. 2025. PMID: 41286109 Free PMC article.
A New Fragment-Based Pharmacophore Virtual Screening Workflow Identifies Potent Inhibitors of SARS-CoV-2 NSP13 Helicase.
Doijen J, Xie J, Marsili S, Bains T, Mann MK, Abeywickrema P, Van den Broeck N, Permann C, Langer T, Ibis G, Mattelaer CA, Harvey J, van Raalte S, Fino R, Pande V, Peeters D, Patrick A, Van Damme E, van Vlijmen H, Van Loock M, Jacoby E. Doijen J, et al. J Comput Chem. 2025 Sep 5;46(23):e70201. doi: 10.1002/jcc.70201. J Comput Chem. 2025. PMID: 40910569 Free PMC article.
A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein.
Van Damme E, Abeywickrema P, Yin Y, Xie J, Jacobs S, Mann MK, Doijen J, Miller R, Piassek M, Marsili S, Subramanian M, Gottlieb L, Abdelnabi R, Van Gool M, Van den Broeck N, De Pauw I, Diels A, Vermeulen P, Temmerman K, Scobey T, Mattocks M, Schäfer A, Jochmans D, De Jonghe S, Leyssen P, Chiu W, Diosa Toro M, Zwaagstra M, Leijs AA, De Gruyter HLM, Buyck C, Van Den Heede K, Jacobs F, Van den Eynde C, Thijs L, Raeymaekers V, Miller S, Del Rosario A, Neyts J, Peeters D, Baric RS, van Kuppeveld FJM, Snijder EJ, van Hemert MJ, Monshouwer M, Sharma S, Draghia-Akli R, Koul A, Van Loock M. Van Damme E, et al. Among authors: doijen j. Nature. 2025 Apr;640(8058):506-513. doi: 10.1038/s41586-025-08651-6. Epub 2025 Mar 26. Nature. 2025. PMID: 40140563 Free PMC article.
A flexible, image-based, high-throughput platform encompassing in-depth cell profiling to identify broad-spectrum coronavirus antivirals with limited off-target effects.
Doijen J, Heo I, Temmerman K, Vermeulen P, Diels A, Jaensch S, Burcin M, Van den Broeck N, Raeymaekers V, Peremans J, Konings K, Clement M, Peeters D, Van Loock M, Koul A, Buyck C, Van Gool M, Van Damme E. Doijen J, et al. Antiviral Res. 2024 Feb;222:105789. doi: 10.1016/j.antiviral.2023.105789. Epub 2023 Dec 27. Antiviral Res. 2024. PMID: 38158129 Free article.
Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2.
Doijen J, Temmerman K, Van den Eynde C, Diels A, Van den Broeck N, Van Gool M, Heo I, Jaensch S, Zwaagstra M, Diosa Toro M, Chiu W, De Jonghe S, Leyssen P, Bojkova D, Ciesek S, Cinatl J, Verschueren L, Buyck C, Van Kuppeveld F, Neyts J, Van Loock M, Van Damme E. Doijen J, et al. Microorganisms. 2023 Mar 10;11(3):717. doi: 10.3390/microorganisms11030717. Microorganisms. 2023. PMID: 36985290 Free PMC article.
17 results