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The CD8+ T cell repertoire against Her-2/neu antigens in neu transgenic mice is of low avidity with antitumor activity.
Lustgarten J, Dominguez AL, Cuadros C. Lustgarten J, et al. Among authors: dominguez al. Eur J Immunol. 2004 Mar;34(3):752-761. doi: 10.1002/eji.200324427. Eur J Immunol. 2004. PMID: 14991605
Cooperative effect between immunotherapy and antiangiogenic therapy leads to effective tumor rejection in tolerant Her-2/neu mice.
Cuadros C, Dominguez AL, Frost GI, Borgstrom P, Lustgarten J. Cuadros C, et al. Among authors: dominguez al. Cancer Res. 2003 Sep 15;63(18):5895-901. Cancer Res. 2003. PMID: 14522915
Flagellin fusion proteins as adjuvants or vaccines induce specific immune responses.
Cuadros C, Lopez-Hernandez FJ, Dominguez AL, McClelland M, Lustgarten J. Cuadros C, et al. Among authors: dominguez al. Infect Immun. 2004 May;72(5):2810-6. doi: 10.1128/iai.72.5.2810-2816.2004. Infect Immun. 2004. PMID: 15102791 Free PMC article.
Aged mice develop protective antitumor immune responses with appropriate costimulation.
Lustgarten J, Dominguez AL, Thoman M. Lustgarten J, et al. Among authors: dominguez al. J Immunol. 2004 Oct 1;173(7):4510-5. doi: 10.4049/jimmunol.173.7.4510. J Immunol. 2004. PMID: 15383582
Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces T cell-mediated protective immunity in Her-2/neu transgenic mice.
Cuadros C, Dominguez AL, Lollini PL, Croft M, Mittler RS, Borgström P, Lustgarten J. Cuadros C, et al. Among authors: dominguez al. Int J Cancer. 2005 Oct 10;116(6):934-43. doi: 10.1002/ijc.21098. Int J Cancer. 2005. PMID: 15856473
Aging affect the anti-tumor potential of dendritic cell vaccination, but it can be overcome by co-stimulation with anti-OX40 or anti-4-1BB.
Sharma S, Dominguez AL, Lustgarten J. Sharma S, et al. Among authors: dominguez al. Exp Gerontol. 2006 Jan;41(1):78-84. doi: 10.1016/j.exger.2005.10.002. Epub 2005 Nov 14. Exp Gerontol. 2006. PMID: 16289924
Identification of cross-reactive peptides using combinatorial libraries circumvents tolerance against Her-2/neu-immunodominant epitope.
Lustgarten J, Dominguez AL, Pinilla C. Lustgarten J, et al. Among authors: dominguez al. J Immunol. 2006 Feb 1;176(3):1796-805. doi: 10.4049/jimmunol.176.3.1796. J Immunol. 2006. PMID: 16424210
High accumulation of T regulatory cells prevents the activation of immune responses in aged animals.
Sharma S, Dominguez AL, Lustgarten J. Sharma S, et al. Among authors: dominguez al. J Immunol. 2006 Dec 15;177(12):8348-55. doi: 10.4049/jimmunol.177.12.8348. J Immunol. 2006. PMID: 17142731
CpG-ODN but not other TLR-ligands restore the antitumor responses in old mice: the implications for vaccinations in the aged.
Sharma S, Dominguez AL, Hoelzinger DB, Lustgarten J. Sharma S, et al. Among authors: dominguez al. Cancer Immunol Immunother. 2008 Apr;57(4):549-61. doi: 10.1007/s00262-007-0393-1. Epub 2007 Sep 8. Cancer Immunol Immunother. 2008. PMID: 17828396
Implications of aging and self-tolerance on the generation of immune and antitumor immune responses.
Dominguez AL, Lustgarten J. Dominguez AL, et al. Cancer Res. 2008 Jul 1;68(13):5423-31. doi: 10.1158/0008-5472.CAN-07-6436. Cancer Res. 2008. PMID: 18593945
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