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Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors.
Pöhlmann S, Davis C, Meister S, Leslie GJ, Otto C, Reeves JD, Puffer BA, Papkalla A, Krumbiegel M, Marzi A, Lorenz S, Münch J, Doms RW, Kirchhoff F. Pöhlmann S, et al. Among authors: doms rw. J Virol. 2004 Apr;78(7):3223-32. doi: 10.1128/jvi.78.7.3223-3232.2004. J Virol. 2004. PMID: 15016843 Free PMC article.
A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo.
Pöhlmann S, Münch J, Aziz S, Reeves JD, Otto C, Leslie GJ, Hofmann H, Puffer BA, Baribaud F, Marzi A, Gramberg T, Chen Z, Stolte N, Haaft PT, Heeney JL, Stahl-Hennig C, Mätz-Rensing K, Schneider T, Doms RW, Kirchhoff F. Pöhlmann S, et al. Among authors: doms rw. Virology. 2007 Apr 10;360(2):275-85. doi: 10.1016/j.virol.2006.10.020. Epub 2006 Nov 28. Virology. 2007. PMID: 17126374 Free article.
An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus.
Edinger AL, Hoffman TL, Sharron M, Lee B, Yi Y, Choe W, Kolson DL, Mitrovic B, Zhou Y, Faulds D, Collman RG, Hesselgesser J, Horuk R, Doms RW. Edinger AL, et al. Among authors: doms rw. J Virol. 1998 Oct;72(10):7934-40. doi: 10.1128/JVI.72.10.7934-7940.1998. J Virol. 1998. PMID: 9733831 Free PMC article.
251 results