Donegan RK - Search Results

1

Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.

Donegan RK, Lieberman RL. Donegan RK, et al. J Med Chem. 2016 Feb 11;59(3):788-809. doi: 10.1021/acs.jmedchem.5b00828. Epub 2015 Sep 25. J Med Chem. 2016. PMID: 26356532 Free PMC article. Review.

2

The glaucoma-associated olfactomedin domain of myocilin is a novel calcium binding protein.

Donegan RK, Hill SE, Turnage KC, Orwig SD, Lieberman RL. Donegan RK, et al. J Biol Chem. 2012 Dec 21;287(52):43370-7. doi: 10.1074/jbc.M112.408906. Epub 2012 Nov 5. J Biol Chem. 2012. PMID: 23129764 Free PMC article.

3

New direction for glaucoma therapeutics: focus on the olfactomedin domain of myocilin.

Donegan RK, Lieberman RL. Donegan RK, et al. Future Med Chem. 2012 Nov;4(17):2131-4. doi: 10.4155/fmc.12.132. Future Med Chem. 2012. PMID: 23190098 No abstract available.

4

The glaucoma-associated olfactomedin domain of myocilin forms polymorphic fibrils that are constrained by partial unfolding and peptide sequence.

Hill SE, Donegan RK, Lieberman RL. Hill SE, et al. Among authors: donegan rk. J Mol Biol. 2014 Feb 20;426(4):921-35. doi: 10.1016/j.jmb.2013.12.002. Epub 2013 Dec 9. J Mol Biol. 2014. PMID: 24333014 Free PMC article.

5

Structural basis for misfolding in myocilin-associated glaucoma.

Donegan RK, Hill SE, Freeman DM, Nguyen E, Orwig SD, Turnage KC, Lieberman RL. Donegan RK, et al. Hum Mol Genet. 2015 Apr 15;24(8):2111-24. doi: 10.1093/hmg/ddu730. Epub 2014 Dec 18. Hum Mol Genet. 2015. PMID: 25524706 Free PMC article.

6

Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies.

Hill SE, Donegan RK, Nguyen E, Desai TM, Lieberman RL. Hill SE, et al. Among authors: donegan rk. PLoS One. 2015 Jun 29;10(6):e0130888. doi: 10.1371/journal.pone.0130888. eCollection 2015. PLoS One. 2015. PMID: 26121352 Free PMC article.

7

Heme and hemoglobin suppress amyloid β-mediated inflammatory activation of mouse astrocytes.

Sankar SB, Donegan RK, Shah KJ, Reddi AR, Wood LB. Sankar SB, et al. Among authors: donegan rk. J Biol Chem. 2018 Jul 20;293(29):11358-11373. doi: 10.1074/jbc.RA117.001050. Epub 2018 Jun 5. J Biol Chem. 2018. PMID: 29871926 Free PMC article.

8

A blueprint for academic labs to produce SARS-CoV-2 RT-qPCR test kits.

Mascuch SJ, Fakhretaha-Aval S, Bowman JC, Ma MTH, Thomas G, Bommarius B, Ito C, Zhao L, Newnam GP, Matange KR, Thapa HR, Barlow B, Donegan RK, Nguyen NA, Saccuzzo EG, Obianyor CT, Karunakaran SC, Pollet P, Rothschild-Mancinelli B, Mestre-Fos S, Guth-Metzler R, Bryksin AV, Petrov AS, Hazell M, Ibberson CB, Penev PI, Mannino RG, Lam WA, Garcia AJ, Kubanek JM, Agarwal V, Hud NV, Glass JB, Williams LD, Lieberman RL. Mascuch SJ, et al. Among authors: donegan rk. medRxiv. 2020 Sep 1:2020.07.29.20163949. doi: 10.1101/2020.07.29.20163949. Preprint. medRxiv. 2020. PMID: 32766604 Free PMC article. Updated.

9

A blueprint for academic laboratories to produce SARS-CoV-2 quantitative RT-PCR test kits.

Mascuch SJ, Fakhretaha-Aval S, Bowman JC, Ma MTH, Thomas G, Bommarius B, Ito C, Zhao L, Newnam GP, Matange KR, Thapa HR, Barlow B, Donegan RK, Nguyen NA, Saccuzzo EG, Obianyor CT, Karunakaran SC, Pollet P, Rothschild-Mancinelli B, Mestre-Fos S, Guth-Metzler R, Bryksin AV, Petrov AS, Hazell M, Ibberson CB, Penev PI, Mannino RG, Lam WA, Garcia AJ, Kubanek J, Agarwal V, Hud NV, Glass JB, Williams LD, Lieberman RL. Mascuch SJ, et al. Among authors: donegan rk. J Biol Chem. 2020 Nov 13;295(46):15438-15453. doi: 10.1074/jbc.RA120.015434. Epub 2020 Sep 3. J Biol Chem. 2020. PMID: 32883809 Free PMC article.

10

Structure and Misfolding of the Flexible Tripartite Coiled-Coil Domain of Glaucoma-Associated Myocilin.

Hill SE, Nguyen E, Donegan RK, Patterson-Orazem AC, Hazel A, Gumbart JC, Lieberman RL. Hill SE, et al. Among authors: donegan rk. Structure. 2017 Nov 7;25(11):1697-1707.e5. doi: 10.1016/j.str.2017.09.008. Structure. 2017. PMID: 29056483 Free PMC article.

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