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Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins.
Neuzil J, Wang XF, Dong LF, Low P, Ralph SJ. Neuzil J, et al. FEBS Lett. 2006 Oct 2;580(22):5125-9. doi: 10.1016/j.febslet.2006.05.072. Epub 2006 Jun 12. FEBS Lett. 2006. PMID: 16979626 Review.
Vitamin E analogs, a novel group of "mitocans," as anticancer agents: the importance of being redox-silent.
Neuzil J, Tomasetti M, Zhao Y, Dong LF, Birringer M, Wang XF, Low P, Wu K, Salvatore BA, Ralph SJ. Neuzil J, et al. Mol Pharmacol. 2007 May;71(5):1185-99. doi: 10.1124/mol.106.030122. Epub 2007 Jan 12. Mol Pharmacol. 2007. PMID: 17220355 Review.
Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II.
Neuzil J, Dyason JC, Freeman R, Dong LF, Prochazka L, Wang XF, Scheffler I, Ralph SJ. Neuzil J, et al. J Bioenerg Biomembr. 2007 Feb;39(1):65-72. doi: 10.1007/s10863-006-9060-z. J Bioenerg Biomembr. 2007. PMID: 17294131 Review.
Tumour-initiating cells vs. cancer 'stem' cells and CD133: what's in the name?
Neuzil J, Stantic M, Zobalova R, Chladova J, Wang X, Prochazka L, Dong L, Andera L, Ralph SJ. Neuzil J, et al. Biochem Biophys Res Commun. 2007 Apr 20;355(4):855-9. doi: 10.1016/j.bbrc.2007.01.159. Epub 2007 Feb 6. Biochem Biophys Res Commun. 2007. PMID: 17307142 Review.
A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression.
Wang XF, Birringer M, Dong LF, Veprek P, Low P, Swettenham E, Stantic M, Yuan LH, Zobalova R, Wu K, Ledvina M, Ralph SJ, Neuzil J. Wang XF, et al. Cancer Res. 2007 Apr 1;67(7):3337-44. doi: 10.1158/0008-5472.CAN-06-2480. Cancer Res. 2007. PMID: 17409443
Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria.
Neuzil J, Dong LF, Ramanathapuram L, Hahn T, Chladova M, Wang XF, Zobalova R, Prochazka L, Gold M, Freeman R, Turanek J, Akporiaye ET, Dyason JC, Ralph SJ. Neuzil J, et al. Mol Aspects Med. 2007 Oct-Dec;28(5-6):607-45. doi: 10.1016/j.mam.2007.02.003. Epub 2007 Feb 23. Mol Aspects Med. 2007. PMID: 17499351 Review.
Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injury.
Neuzil J, Widén C, Gellert N, Swettenham E, Zobalova R, Dong LF, Wang XF, Lidebjer C, Dalen H, Headrick JP, Witting PK. Neuzil J, et al. Redox Rep. 2007;12(3):148-62. doi: 10.1179/135100007X200227. Redox Rep. 2007. PMID: 17623522
alpha-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling.
Neuzil J, Swettenham E, Wang XF, Dong LF, Stapelberg M. Neuzil J, et al. FEBS Lett. 2007 Oct 2;581(24):4611-5. doi: 10.1016/j.febslet.2007.08.051. Epub 2007 Aug 31. FEBS Lett. 2007. PMID: 17825301
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