Dong W - Search Results

1

Acidic pH or salt treatment can convert soluble antibody aggregates in culture harvest into monomers and improve Protein A chromatography step yield.

Zhang T, Li B, Dong W, Wan Y, Li Y. Zhang T, et al. Among authors: dong w. Protein Expr Purif. 2024 Mar;215:106391. doi: 10.1016/j.pep.2023.106391. Epub 2023 Nov 7. Protein Expr Purif. 2024. PMID: 37939750

2

Obtaining acidic and basic charge variants using a twin-column continuous chromatography system.

Yuan G, Zhang X, Zhang Y, Dong W, Li Y. Yuan G, et al. Among authors: dong w. Protein Expr Purif. 2023 Mar;203:106217. doi: 10.1016/j.pep.2022.106217. Epub 2022 Dec 15. Protein Expr Purif. 2023. PMID: 36529448

3

Protein A and CaptureSelect FcXP Affinity Resins Possess the Capability of Differentiating Hole-hole Homodimer Isoforms.

Wang J, Tian M, Dong W, Zhang X, Li Y. Wang J, et al. Among authors: dong w. Protein Pept Lett. 2023;30(6):498-505. doi: 10.2174/0929866530666230516122012. Protein Pept Lett. 2023. PMID: 37194234

4

Antibody aggregation can lead to reduced Protein A binding capacity and low step yield.

Yuan G, Qu M, Geng Q, Dong W, Zhang X, Li Y. Yuan G, et al. Among authors: dong w. Protein Expr Purif. 2023 Oct;210:106315. doi: 10.1016/j.pep.2023.106315. Epub 2023 Jun 2. Protein Expr Purif. 2023. PMID: 37271409

5

Complementary methods for monitoring hole-hole homodimer associated with a WuXiBody-based asymmetric bispecific antibody.

Dong W, Li Y. Dong W, et al. Protein Expr Purif. 2023 Oct;210:106316. doi: 10.1016/j.pep.2023.106316. Epub 2023 Jun 2. Protein Expr Purif. 2023. PMID: 37271410

6

SEC-HPLC analysis of column load and flow-through provides critical understanding of low Protein A step yield.

Liu C, Tian M, Dong W, Lu W, Zhang T, Wan Y, Zhang X, Li Y. Liu C, et al. Among authors: dong w. Protein Expr Purif. 2024 Apr;216:106418. doi: 10.1016/j.pep.2023.106418. Epub 2023 Dec 21. Protein Expr Purif. 2024. PMID: 38141898

7

Unravelling the reason for different binding behaviors exhibited by antibody aggregates towards preparative and analytical Protein A columns.

Dong W, Tian M, Li Y. Dong W, et al. Protein Expr Purif. 2024 Jun;218:106449. doi: 10.1016/j.pep.2024.106449. Epub 2024 Feb 27. Protein Expr Purif. 2024. PMID: 38423157

8

CaptureSelect FcXP affinity medium exhibits strong aggregate separation capability.

Dong W, Zhang D, Li Y. Dong W, et al. Protein Expr Purif. 2024 Aug;220:106503. doi: 10.1016/j.pep.2024.106503. Epub 2024 May 15. Protein Expr Purif. 2024. PMID: 38759705

9

Monitoring of the disulfide scrambled species by mixed-mode SEC-HPLC during the purification of a bispecific antibody.

Tian M, Li D, Hu L, Dong W, Wang T, Li Y. Tian M, et al. Among authors: dong w. Protein Expr Purif. 2024 Nov;223:106544. doi: 10.1016/j.pep.2024.106544. Epub 2024 Jul 6. Protein Expr Purif. 2024. PMID: 38972616

10

CH1-specific affinity resins possess the potential of separating heterodimer from homodimers in asymmetric bispecific antibody purification.

Dong W, Li Y. Dong W, et al. J Biol Methods. 2024 Sep 3;11(3):e99010020. doi: 10.14440/jbm.2024.0026. eCollection 2024. J Biol Methods. 2024. PMID: 39544192 Free PMC article.

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