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The role of kinetic context in apparent biased agonism at GPCRs.
Klein Herenbrink C, Sykes DA, Donthamsetti P, Canals M, Coudrat T, Shonberg J, Scammells PJ, Capuano B, Sexton PM, Charlton SJ, Javitch JA, Christopoulos A, Lane JR. Klein Herenbrink C, et al. Among authors: donthamsetti p. Nat Commun. 2016 Feb 24;7:10842. doi: 10.1038/ncomms10842. Nat Commun. 2016. PMID: 26905976 Free PMC article.
Optical control of sphingosine-1-phosphate formation and function.
Morstein J, Hill RZ, Novak AJE, Feng S, Norman DD, Donthamsetti PC, Frank JA, Harayama T, Williams BM, Parrill AL, Tigyi GJ, Riezman H, Isacoff EY, Bautista DM, Trauner D. Morstein J, et al. Among authors: donthamsetti pc. Nat Chem Biol. 2019 Jun;15(6):623-631. doi: 10.1038/s41589-019-0269-7. Epub 2019 Apr 29. Nat Chem Biol. 2019. PMID: 31036923 Free PMC article.
Optical Control of Lysophosphatidic Acid Signaling.
Morstein J, Dacheux MA, Norman DD, Shemet A, Donthamsetti PC, Citir M, Frank JA, Schultz C, Isacoff EY, Parrill AL, Tigyi GJ, Trauner D. Morstein J, et al. Among authors: donthamsetti pc. J Am Chem Soc. 2020 Jun 17;142(24):10612-10616. doi: 10.1021/jacs.0c02154. Epub 2020 Jun 5. J Am Chem Soc. 2020. PMID: 32469525 Free PMC article.
Photopharmacology for vision restoration.
Berry MH, Holt A, Broichhagen J, Donthamsetti P, Flannery JG, Isacoff EY. Berry MH, et al. Among authors: donthamsetti p. Curr Opin Pharmacol. 2022 Aug;65:102259. doi: 10.1016/j.coph.2022.102259. Epub 2022 Jun 21. Curr Opin Pharmacol. 2022. PMID: 35749908 Free article. Review.
A new mechanism of allostery in a G protein-coupled receptor dimer.
Lane JR, Donthamsetti P, Shonberg J, Draper-Joyce CJ, Dentry S, Michino M, Shi L, López L, Scammells PJ, Capuano B, Sexton PM, Javitch JA, Christopoulos A. Lane JR, et al. Among authors: donthamsetti p. Nat Chem Biol. 2014 Sep;10(9):745-52. doi: 10.1038/nchembio.1593. Epub 2014 Aug 10. Nat Chem Biol. 2014. PMID: 25108820 Free PMC article.
24 results