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Evidence that several conserved histidine residues are required for hydrolytic activity of human paraoxonase/arylesterase.
Doorn JA, Sorenson RC, Billecke SS, Hsu C, La Du BN. Doorn JA, et al. Chem Biol Interact. 1999 May 14;119-120:235-41. doi: 10.1016/s0009-2797(99)00032-0. Chem Biol Interact. 1999. PMID: 10421457
Probing the active sites of butyrylcholinesterase and cholesterol esterase with isomalathion: conserved stereoselective inactivation of serine hydrolases structurally related to acetylcholinesterase.
Doorn JA, Talley TT, Thompson CM, Richardson RJ. Doorn JA, et al. Chem Res Toxicol. 2001 Jul;14(7):807-13. doi: 10.1021/tx015501s. Chem Res Toxicol. 2001. PMID: 11453726
Characterization of a soluble mouse liver enzyme capable of hydrolyzing diisopropyl phosphorofluoridate.
Billecke SS, Primo-Parmo SL, Dunlop CS, Doorn JA, La Du BN, Broomfield CA. Billecke SS, et al. Among authors: doorn ja. Chem Biol Interact. 1999 May 14;119-120:251-6. doi: 10.1016/s0009-2797(99)00034-4. Chem Biol Interact. 1999. PMID: 10421459
Identification of butyrylcholinesterase adducts after inhibition with isomalathion using mass spectrometry: difference in mechanism between (1R)- and (1S)-stereoisomers.
Doorn JA, Schall M, Gage DA, Talley TT, Thompson CM, Richardson RJ. Doorn JA, et al. Toxicol Appl Pharmacol. 2001 Oct 15;176(2):73-80. doi: 10.1006/taap.2001.9279. Toxicol Appl Pharmacol. 2001. PMID: 11601883
Stereoselective inactivation of Torpedo californica acetylcholinesterase by isomalathion: inhibitory reactions with (1R)- and (1S)-isomers proceed by different mechanisms.
Doorn JA, Thompson CM, Christner RB, Richardson RJ. Doorn JA, et al. Chem Res Toxicol. 2003 Aug;16(8):958-65. doi: 10.1021/tx030026e. Chem Res Toxicol. 2003. PMID: 12924923
Inhibition of acetylcholinesterase by (1S,3S)-isomalathion proceeds with loss of thiomethyl: kinetic and mass spectral evidence for an unexpected primary leaving group.
Doorn JA, Gage DA, Schall M, Talley TT, Thompson CM, Richardson RJ. Doorn JA, et al. Chem Res Toxicol. 2000 Dec;13(12):1313-20. doi: 10.1021/tx000184v. Chem Res Toxicol. 2000. PMID: 11123973
PCB95 and PCB153 change dopamine levels and turn-over in PC12 cells.
Enayah SH, Vanle BC, Fuortes LJ, Doorn JA, Ludewig G. Enayah SH, et al. Among authors: doorn ja. Toxicology. 2018 Feb 1;394:93-101. doi: 10.1016/j.tox.2017.12.003. Epub 2017 Dec 9. Toxicology. 2018. PMID: 29233657 Free PMC article.
Covalent modification of amino acid nucleophiles by the lipid peroxidation products 4-hydroxy-2-nonenal and 4-oxo-2-nonenal.
Doorn JA, Petersen DR. Doorn JA, et al. Chem Res Toxicol. 2002 Nov;15(11):1445-50. doi: 10.1021/tx025590o. Chem Res Toxicol. 2002. PMID: 12437335
Covalent adduction of nucleophilic amino acids by 4-hydroxynonenal and 4-oxononenal.
Doorn JA, Petersen DR. Doorn JA, et al. Chem Biol Interact. 2003 Feb 1;143-144:93-100. doi: 10.1016/s0009-2797(02)00178-3. Chem Biol Interact. 2003. PMID: 12604193
Lipid aldehyde-mediated cross-linking of apolipoprotein B-100 inhibits secretion from HepG2 cells.
Stewart BJ, Roede JR, Doorn JA, Petersen DR. Stewart BJ, et al. Among authors: doorn ja. Biochim Biophys Acta. 2009 Aug;1791(8):772-80. doi: 10.1016/j.bbalip.2009.04.004. Epub 2009 Apr 21. Biochim Biophys Acta. 2009. PMID: 19393338 Free PMC article.
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