Dorko K - Search Results

1

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.

Xie Y, McGill MR, Dorko K, Kumer SC, Schmitt TM, Forster J, Jaeschke H. Xie Y, et al. Among authors: dorko k. Toxicol Appl Pharmacol. 2014 Sep 15;279(3):266-274. doi: 10.1016/j.taap.2014.05.010. Epub 2014 Jun 3. Toxicol Appl Pharmacol. 2014. PMID: 24905542 Free PMC article.

2

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis.

Woolbright BL, Dorko K, Antoine DJ, Clarke JI, Gholami P, Li F, Kumer SC, Schmitt TM, Forster J, Fan F, Jenkins RE, Park BK, Hagenbuch B, Olyaee M, Jaeschke H. Woolbright BL, et al. Among authors: dorko k. Toxicol Appl Pharmacol. 2015 Mar 15;283(3):168-77. doi: 10.1016/j.taap.2015.01.015. Epub 2015 Jan 28. Toxicol Appl Pharmacol. 2015. PMID: 25636263 Free PMC article.

3

Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.

Xie Y, McGill MR, Du K, Dorko K, Kumer SC, Schmitt TM, Ding WX, Jaeschke H. Xie Y, et al. Among authors: dorko k. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):213-22. doi: 10.1016/j.taap.2015.09.022. Epub 2015 Sep 30. Toxicol Appl Pharmacol. 2015. PMID: 26431796 Free PMC article.

4

Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity.

Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H. Xie Y, et al. Among authors: dorko k. J Clin Transl Res. 2015;1(2):100-106. doi: 10.18053/jctres.201502.004. Epub 2015 Sep 30. J Clin Transl Res. 2015. PMID: 26722668 Free PMC article.

5

Lack of direct cytotoxicity of extracellular ATP against hepatocytes: role in the mechanism of acetaminophen hepatotoxicity.

Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H. Xie Y, et al. Among authors: dorko k. J Clin Transl Res. 2015 Sep 30;1(2):1-7. eCollection 2015 Sep 30. J Clin Transl Res. 2015. PMID: 30873447 Free PMC article.

6

Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury.

Wang S, Ni HM, Dorko K, Kumer SC, Schmitt TM, Nawabi A, Komatsu M, Huang H, Ding WX. Wang S, et al. Among authors: dorko k. Oncotarget. 2016 Apr 5;7(14):17681-98. doi: 10.18632/oncotarget.6893. Oncotarget. 2016. PMID: 26769846 Free PMC article.

7

Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver.

Chavan H, Li F, Tessman R, Mickey K, Dorko K, Schmitt T, Kumer S, Gunewardena S, Gaikwad N, Krishnamurthy P. Chavan H, et al. Among authors: dorko k. J Biol Chem. 2015 Mar 20;290(12):7871-86. doi: 10.1074/jbc.M114.605386. Epub 2015 Jan 26. J Biol Chem. 2015. PMID: 25623066 Free PMC article.

8

Serine 574 phosphorylation alters transcriptional programming of FOXO3 by selectively enhancing apoptotic gene expression.

Li Z, Zhao J, Tikhanovich I, Kuravi S, Helzberg J, Dorko K, Roberts B, Kumer S, Weinman SA. Li Z, et al. Among authors: dorko k. Cell Death Differ. 2016 Apr;23(4):583-95. doi: 10.1038/cdd.2015.125. Epub 2015 Oct 16. Cell Death Differ. 2016. PMID: 26470730 Free PMC article.

9

The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases.

Hansel MC, Davila JC, Vosough M, Gramignoli R, Skvorak KJ, Dorko K, Marongiu F, Blake W, Strom SC. Hansel MC, et al. Among authors: dorko k. Curr Protoc Toxicol. 2016 Feb 1;67:14.13.1-14.13.27. doi: 10.1002/0471140856.tx1413s67. Curr Protoc Toxicol. 2016. PMID: 26828329 Free PMC article. Review.

10

The history and use of human hepatocytes for the treatment of liver diseases: the first 100 patients.

Hansel MC, Gramignoli R, Skvorak KJ, Dorko K, Marongiu F, Blake W, Davila J, Strom SC. Hansel MC, et al. Among authors: dorko k. Curr Protoc Toxicol. 2014 Nov 6;62:14.12.1-23. doi: 10.1002/0471140856.tx1412s62. Curr Protoc Toxicol. 2014. PMID: 25378242 Free PMC article.

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