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G-protein-coupled receptors and cancer.
Dorsam RT, Gutkind JS. Dorsam RT, et al. Nat Rev Cancer. 2007 Feb;7(2):79-94. doi: 10.1038/nrc2069. Nat Rev Cancer. 2007. PMID: 17251915 Review.
SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.
Dillenburg-Pilla P, Patel V, Mikelis CM, Zárate-Bladés CR, Doçi CL, Amornphimoltham P, Wang Z, Martin D, Leelahavanichkul K, Dorsam RT, Masedunskas A, Weigert R, Molinolo AA, Gutkind JS. Dillenburg-Pilla P, et al. Among authors: dorsam rt. FASEB J. 2015 Mar;29(3):1056-68. doi: 10.1096/fj.14-260083. Epub 2014 Dec 2. FASEB J. 2015. PMID: 25466898 Free PMC article.
A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.
Vaqué JP, Dorsam RT, Feng X, Iglesias-Bartolome R, Forsthoefel DJ, Chen Q, Debant A, Seeger MA, Ksander BR, Teramoto H, Gutkind JS. Vaqué JP, et al. Among authors: dorsam rt. Mol Cell. 2013 Jan 10;49(1):94-108. doi: 10.1016/j.molcel.2012.10.018. Epub 2012 Nov 21. Mol Cell. 2013. PMID: 23177739 Free PMC article.
Vandetanib for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease: U.S. Food and Drug Administration drug approval summary.
Thornton K, Kim G, Maher VE, Chattopadhyay S, Tang S, Moon YJ, Song P, Marathe A, Balakrishnan S, Zhu H, Garnett C, Liu Q, Booth B, Gehrke B, Dorsam R, Verbois L, Ghosh D, Wilson W, Duan J, Sarker H, Miksinski SP, Skarupa L, Ibrahim A, Justice R, Murgo A, Pazdur R. Thornton K, et al. Clin Cancer Res. 2012 Jul 15;18(14):3722-30. doi: 10.1158/1078-0432.CCR-12-0411. Epub 2012 Jun 4. Clin Cancer Res. 2012. PMID: 22665903 Clinical Trial.
Platelet purinergic receptors.
Kunapuli SP, Dorsam RT, Kim S, Quinton TM. Kunapuli SP, et al. Among authors: dorsam rt. Curr Opin Pharmacol. 2003 Apr;3(2):175-80. doi: 10.1016/s1471-4892(03)00007-9. Curr Opin Pharmacol. 2003. PMID: 12681240 Review.
23 results