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siRNAs: applications in functional genomics and potential as therapeutics.
Dorsett Y, Tuschl T. Dorsett Y, et al. Nat Rev Drug Discov. 2004 Apr;3(4):318-29. doi: 10.1038/nrd1345. Nat Rev Drug Discov. 2004. PMID: 15060527 Review. No abstract available.
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T. Meister G, et al. Mol Cell. 2004 Jul 23;15(2):185-97. doi: 10.1016/j.molcel.2004.07.007. Mol Cell. 2004. PMID: 15260970
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.
Meister G, Landthaler M, Dorsett Y, Tuschl T. Meister G, et al. RNA. 2004 Mar;10(3):544-50. doi: 10.1261/rna.5235104. RNA. 2004. PMID: 14970398 Free PMC article.
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.
Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC. Robbiani DF, et al. Among authors: dorsett y. Cell. 2008 Dec 12;135(6):1028-38. doi: 10.1016/j.cell.2008.09.062. Cell. 2008. PMID: 19070574 Free PMC article.
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation.
Dorsett Y, McBride KM, Jankovic M, Gazumyan A, Thai TH, Robbiani DF, Di Virgilio M, Reina San-Martin B, Heidkamp G, Schwickert TA, Eisenreich T, Rajewsky K, Nussenzweig MC. Dorsett Y, et al. Immunity. 2008 May;28(5):630-8. doi: 10.1016/j.immuni.2008.04.002. Epub 2008 May 1. Immunity. 2008. PMID: 18455451 Free PMC article.
HCoDES reveals chromosomal DNA end structures with single-nucleotide resolution.
Dorsett Y, Zhou Y, Tubbs AT, Chen BR, Purman C, Lee BS, George R, Bredemeyer AL, Zhao JY, Sodergen E, Weinstock GM, Han ND, Reyes A, Oltz EM, Dorsett D, Misulovin Z, Payton JE, Sleckman BP. Dorsett Y, et al. Mol Cell. 2014 Dec 18;56(6):808-18. doi: 10.1016/j.molcel.2014.10.024. Epub 2014 Nov 26. Mol Cell. 2014. PMID: 25435138 Free PMC article.
KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes.
Tubbs AT, Dorsett Y, Chan E, Helmink B, Lee BS, Hung P, George R, Bredemeyer AL, Mittal A, Pappu RV, Chowdhury D, Mosammaparast N, Krangel MS, Sleckman BP. Tubbs AT, et al. Among authors: dorsett y. Mol Cell Biol. 2014 Aug;34(15):2811-21. doi: 10.1128/MCB.00441-14. Epub 2014 May 19. Mol Cell Biol. 2014. PMID: 24842905 Free PMC article.
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
Helmink BA, Tubbs AT, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP. Helmink BA, et al. Among authors: dorsett y. Nature. 2011 Jan 13;469(7329):245-9. doi: 10.1038/nature09585. Epub 2010 Dec 15. Nature. 2011. PMID: 21160476 Free PMC article.
Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo.
Sernández IV, de Yébenes VG, Dorsett Y, Ramiro AR. Sernández IV, et al. Among authors: dorsett y. PLoS One. 2008;3(12):e3927. doi: 10.1371/journal.pone.0003927. Epub 2008 Dec 12. PLoS One. 2008. PMID: 19079594 Free PMC article.
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.
Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP. Gapud EJ, et al. Among authors: dorsett y. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2022-7. doi: 10.1073/pnas.1013295108. Epub 2011 Jan 18. Proc Natl Acad Sci U S A. 2011. PMID: 21245316 Free PMC article.
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