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Bauhinia holophylla (Bong.) Steud. leaves-derived extracts as potent anti-dengue serotype 2.
Dos Santos M, Teixeira TR, Santos FRDS, Lima WG, Ferraz AC, Silva NL, Leite FJ, Siqueira JM, Luyten W, de Castro AHF, de Magalhães JC, Ferreira JMS. Dos Santos M, et al. Nat Prod Res. 2021 Aug;35(16):2804-2809. doi: 10.1080/14786419.2019.1669030. Epub 2019 Sep 26. Nat Prod Res. 2021. PMID: 31554433
As results, the hydroethanolic extract showed the most potent effect, with an inhibitory concentration (IC(50)) of 3.2 mug mL(-1) and selectivity index (SI) of 27.6, approximately 16-times higher anti-DENV-2 activity than of the ribavirin (IC(50) 52.8 mug mL(-1)). . …
As results, the hydroethanolic extract showed the most potent effect, with an inhibitory concentration (IC(50)) of 3.2 mug mL(-1) and …
Evaluation of prolyl oligopeptidase and acetylcholinesterase inhibition by Phyllanthus tenellus Roxb. from Brazil.
Dos Santos MZ, de Ávila J, Morel A, Canto-Dorow TS, Mostardeiro MA, Dalcol II. Dos Santos MZ, et al. Nat Prod Res. 2021 Jun;35(11):1840-1846. doi: 10.1080/14786419.2019.1637869. Epub 2019 Jul 8. Nat Prod Res. 2021. PMID: 31282201
Dichloromethane and ethyl acetate fractions showed the highest inhibitory potency against POP (IC(50) values of 1.7 0.4 and 11.7 2 g/mL, respectively). All fractions were inactive against AChE. Corilagin displayed selective POP inhibition in a dose-dependent manner, with I …
Dichloromethane and ethyl acetate fractions showed the highest inhibitory potency against POP (IC(50) values of 1.7 0.4 and 11.7 2 g/ …
New Δ8,9-pregnene steroids isolated from the extremophile fungus Exophiala oligosperma.
Dos Santos A, Rodrigues-Filho E. Dos Santos A, et al. Nat Prod Res. 2021 Aug;35(15):2598-2601. doi: 10.1080/14786419.2019.1684277. Epub 2019 Nov 1. Nat Prod Res. 2021. PMID: 31674836
Three pregnene steroids, two of them new, were isolated from ethyl-acetate partition of liquid-cultivation of the extremophyle fungus Exophiala oligosperma, found in a pH 1.5 hydrochloric acid aqueous solution. Spectroscopic studies using NMR and HRMS, allowed the identifi …
Three pregnene steroids, two of them new, were isolated from ethyl-acetate partition of liquid-cultivation of the extremophyle fungus Exophi …
Algrizea Minor Sobral, Faria & Proença (Myrteae, Myrtaceae): chemical composition, antinociceptive, antimicrobial and antioxidant activity of essential oil.
de Veras BO, Dos Santos YQ, Oliveira FGDS, Almeida JRGDS, da Silva AG, Correia MTDS, Diniz KM, de Oliveira JRS, Lima VLM, Navarro DMDAF, de Aguiar JCROF, de Oliveira MBM, Lopes ACS, da Silva MV. de Veras BO, et al. Among authors: dos santos yq. Nat Prod Res. 2020 Oct;34(20):3013-3017. doi: 10.1080/14786419.2019.1602832. Epub 2019 Apr 23. Nat Prod Res. 2020. PMID: 31014086
The essential oil presented as the major constituents beta-Pinene (56.99%), alpha-Pinene (16.57%), Germacrene D (4.67%), Bicyclogermacrene (4.66%), (E)-Caryophyllene (3.76%) and Limonene (1.71%). It was verified that the essential oil did not show acute toxicity in the max …
The essential oil presented as the major constituents beta-Pinene (56.99%), alpha-Pinene (16.57%), Germacrene D (4.67%), Bicyclogermacrene ( …
GC×GC/qMS analyses of Campomanesia guazumifolia (Cambess.) O. Berg essential oils and their antioxidant and antimicrobial activity.
Dos Santos AL, Polidoro ADS, Cardoso CAL, Batistote M, do Carmo Vieira M, Jacques RA, Caramão EB. Dos Santos AL, et al. Nat Prod Res. 2019 Feb;33(4):593-597. doi: 10.1080/14786419.2017.1399383. Epub 2017 Nov 5. Nat Prod Res. 2019. PMID: 29105503
Sesquiterpene hydrocarbons (29 compounds) and oxygenated sesquiterpenes (20 compounds) were the most representative classes of terpenes. DPPH (IC(50) value 26.1 0.5 mug/mL) and BCB (68.3 1.5%) values indicated a significant antioxidant activity. The essential oil st …
Sesquiterpene hydrocarbons (29 compounds) and oxygenated sesquiterpenes (20 compounds) were the most representative classes of terpenes. DPP …