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RANK is essential for osteoclast and lymph node development.
Dougall WC, Glaccum M, Charrier K, Rohrbach K, Brasel K, De Smedt T, Daro E, Smith J, Tometsko ME, Maliszewski CR, Armstrong A, Shen V, Bain S, Cosman D, Anderson D, Morrissey PJ, Peschon JJ, Schuh J. Dougall WC, et al. Genes Dev. 1999 Sep 15;13(18):2412-24. doi: 10.1101/gad.13.18.2412. Genes Dev. 1999. PMID: 10500098 Free PMC article.
Poor prognosis of patients with triple-negative breast cancer can be stratified by RANK and RANKL dual expression.
Reyes ME, Fujii T, Branstetter D, Krishnamurthy S, Masuda H, Wang X, Reuben JM, Woodward WA, Edwards BJ, Hortobagyi GN, Tripathy D, Dougall WC, Eckhardt BL, Ueno NT. Reyes ME, et al. Among authors: dougall wc. Breast Cancer Res Treat. 2017 Jul;164(1):57-67. doi: 10.1007/s10549-017-4233-5. Epub 2017 Apr 17. Breast Cancer Res Treat. 2017. PMID: 28417335
RANK expression as a prognostic and predictive marker in breast cancer.
Pfitzner BM, Branstetter D, Loibl S, Denkert C, Lederer B, Schmitt WD, Dombrowski F, Werner M, Rüdiger T, Dougall WC, von Minckwitz G. Pfitzner BM, et al. Among authors: dougall wc. Breast Cancer Res Treat. 2014 Jun;145(2):307-15. doi: 10.1007/s10549-014-2955-1. Epub 2014 Apr 16. Breast Cancer Res Treat. 2014. PMID: 24737168 Clinical Trial.
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