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RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasis.
Palafox M, Ferrer I, Pellegrini P, Vila S, Hernandez-Ortega S, Urruticoechea A, Climent F, Soler MT, Muñoz P, Viñals F, Tometsko M, Branstetter D, Dougall WC, González-Suárez E. Palafox M, et al. Among authors: dougall wc. Cancer Res. 2012 Jun 1;72(11):2879-88. doi: 10.1158/0008-5472.CAN-12-0044. Epub 2012 Apr 10. Cancer Res. 2012. PMID: 22496457
RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini.
Gonzalez-Suarez E, Branstetter D, Armstrong A, Dinh H, Blumberg H, Dougall WC. Gonzalez-Suarez E, et al. Among authors: dougall wc. Mol Cell Biol. 2007 Feb;27(4):1442-54. doi: 10.1128/MCB.01298-06. Epub 2006 Dec 4. Mol Cell Biol. 2007. PMID: 17145767 Free PMC article.
Targeting RANKL in metastasis.
Dougall WC, Holen I, González Suárez E. Dougall WC, et al. Bonekey Rep. 2014 Apr 9;3:519. doi: 10.1038/bonekey.2014.14. eCollection 2014. Bonekey Rep. 2014. PMID: 24795813 Free PMC article. Review.
94 results