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The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects.
Johns DG, Behm DJ, Walker DJ, Ao Z, Shapland EM, Daniels DA, Riddick M, Dowell S, Staton PC, Green P, Shabon U, Bao W, Aiyar N, Yue TL, Brown AJ, Morrison AD, Douglas SA. Johns DG, et al. Among authors: douglas sa. Br J Pharmacol. 2007 Nov;152(5):825-31. doi: 10.1038/sj.bjp.0707419. Epub 2007 Aug 20. Br J Pharmacol. 2007. PMID: 17704827 Free PMC article.
Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues.
Behm DJ, McAtee JJ, Dodson JW, Neeb MJ, Fries HE, Evans CA, Hernandez RR, Hoffman KD, Harrison SM, Lai JM, Wu C, Aiyar NV, Ohlstein EH, Douglas SA. Behm DJ, et al. Among authors: douglas sa. Br J Pharmacol. 2008 Oct;155(3):374-86. doi: 10.1038/bjp.2008.266. Epub 2008 Jun 30. Br J Pharmacol. 2008. PMID: 18587423 Free PMC article.
GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo.
Behm DJ, Aiyar NV, Olzinski AR, McAtee JJ, Hilfiker MA, Dodson JW, Dowdell SE, Wang GZ, Goodman KB, Sehon CA, Harpel MR, Willette RN, Neeb MJ, Leach CA, Douglas SA. Behm DJ, et al. Among authors: douglas sa. Br J Pharmacol. 2010 Sep;161(1):207-28. doi: 10.1111/j.1476-5381.2010.00889.x. Br J Pharmacol. 2010. PMID: 20718751 Free PMC article.
Urotensin-II: a novel systemic hypertensive factor in the cat.
Behm DJ, Doe CP, Johns DG, Maniscalco K, Stankus GP, Wibberley A, Willette RN, Douglas SA. Behm DJ, et al. Among authors: douglas sa. Naunyn Schmiedebergs Arch Pharmacol. 2004 Mar;369(3):274-80. doi: 10.1007/s00210-004-0873-1. Epub 2004 Feb 19. Naunyn Schmiedebergs Arch Pharmacol. 2004. PMID: 14985938
139 results