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Probing phosphoinositide functions in signaling and membrane trafficking.
Downes CP, Gray A, Lucocq JM. Downes CP, et al. Trends Cell Biol. 2005 May;15(5):259-68. doi: 10.1016/j.tcb.2005.03.008. Trends Cell Biol. 2005. PMID: 15866030 Review.
Direct labelling of hormone-sensitive phosphoinositides by a plasma-membrane-associated PtdIns synthase in turkey erythrocytes.
Vaziri C, Downes CP, Macfarlane SC. Vaziri C, et al. Among authors: downes cp. Biochem J. 1993 Sep 15;294 ( Pt 3)(Pt 3):793-9. doi: 10.1042/bj2940793. Biochem J. 1993. PMID: 8397510 Free PMC article.
We have previously characterized phosphatidylinositol (PtdIns) synthase and PtdIns/myo-inositol-exchange enzyme activities in ghost membranes prepared by hypotonic lysis of turkey erythrocytes [McPhee, Lowe, Vaziri and Downes (1991) Biochem. ...These membranes lack PLC act …
We have previously characterized phosphatidylinositol (PtdIns) synthase and PtdIns/myo-inositol-exchange enzyme activities in ghost membrane …
Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.
Davidson L, Maccario H, Perera NM, Yang X, Spinelli L, Tibarewal P, Glancy B, Gray A, Weijer CJ, Downes CP, Leslie NR. Davidson L, et al. Among authors: downes cp. Oncogene. 2010 Feb 4;29(5):687-97. doi: 10.1038/onc.2009.384. Epub 2009 Nov 16. Oncogene. 2010. PMID: 19915616 Free PMC article.
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase.
Leslie NR, Gray A, Pass I, Orchiston EA, Downes CP. Leslie NR, et al. Among authors: downes cp. Biochem J. 2000 Mar 15;346 Pt 3(Pt 3):827-33. Biochem J. 2000. PMID: 10698713 Free PMC article.
Metabolic switching of PI3K-dependent lipid signals.
Downes CP, Leslie NR, Batty IH, van der Kaay J. Downes CP, et al. Biochem Soc Trans. 2007 Apr;35(Pt 2):188-92. doi: 10.1042/BST0350188. Biochem Soc Trans. 2007. PMID: 17371235
Redox regulation of phosphatase function.
Leslie NR, Lindsay Y, Ross SH, Downes CP. Leslie NR, et al. Among authors: downes cp. Biochem Soc Trans. 2004 Dec;32(Pt 6):1018-20. doi: 10.1042/BST0321018. Biochem Soc Trans. 2004. PMID: 15506952
The role of dynamin and its binding partners in coated pit invagination and scission.
Hill E, van Der Kaay J, Downes CP, Smythe E. Hill E, et al. Among authors: downes cp. J Cell Biol. 2001 Jan 22;152(2):309-23. doi: 10.1083/jcb.152.2.309. J Cell Biol. 2001. PMID: 11266448 Free PMC article.
Phosphatidylinositol(3,4,5)trisphosphate (Ptdins(3,4,5)P3) mass measurement using a radioligand displacement assay.
van der Kaay J, Cullen PJ, Downes CP. van der Kaay J, et al. Among authors: downes cp. Methods Mol Biol. 1998;105:109-25. doi: 10.1385/0-89603-491-7:109. Methods Mol Biol. 1998. PMID: 10427555 Review. No abstract available.
DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides.
Dowler S, Currie RA, Downes CP, Alessi DR. Dowler S, et al. Among authors: downes cp. Biochem J. 1999 Aug 15;342 ( Pt 1)(Pt 1):7-12. Biochem J. 1999. PMID: 10432293 Free PMC article.
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR. Balendran A, et al. Among authors: downes cp. Curr Biol. 1999 Apr 22;9(8):393-404. doi: 10.1016/s0960-9822(99)80186-9. Curr Biol. 1999. PMID: 10226025
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