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141 results
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Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity.
Poreba M, Salvesen GS, Drag M. Poreba M, et al. Among authors: drag m. Nat Protoc. 2017 Oct;12(10):2189-2214. doi: 10.1038/nprot.2017.091. Epub 2017 Sep 21. Nat Protoc. 2017. PMID: 28933778
Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs.
Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS. Mikolajczyk J, et al. Among authors: drag m. J Biol Chem. 2007 Sep 7;282(36):26217-24. doi: 10.1074/jbc.M702444200. Epub 2007 Jun 25. J Biol Chem. 2007. PMID: 17591783
Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family.
Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS. Drag M, et al. Biochem J. 2008 Jan 15;409(2):461-9. doi: 10.1042/BJ20070940. Biochem J. 2008. PMID: 17916063
The mechanism of peptide-binding specificity of IAP BIR domains.
Eckelman BP, Drag M, Snipas SJ, Salvesen GS. Eckelman BP, et al. Among authors: drag m. Cell Death Differ. 2008 May;15(5):920-8. doi: 10.1038/cdd.2008.6. Epub 2008 Feb 1. Cell Death Differ. 2008. PMID: 18239672
Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC.
Snipas SJ, Drag M, Stennicke HR, Salvesen GS. Snipas SJ, et al. Among authors: drag m. Cell Death Differ. 2008 May;15(5):938-45. doi: 10.1038/cdd.2008.23. Epub 2008 Feb 29. Cell Death Differ. 2008. PMID: 18309328
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes).
Drag M, Mikolajczyk J, Bekes M, Reyes-Turcu FE, Ellman JA, Wilkinson KD, Salvesen GS. Drag M, et al. Biochem J. 2008 Nov 1;415(3):367-75. doi: 10.1042/BJ20080779. Biochem J. 2008. PMID: 18601651 Free PMC article.
Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.
Drag M, Bogyo M, Ellman JA, Salvesen GS. Drag M, et al. J Biol Chem. 2010 Jan 29;285(5):3310-8. doi: 10.1074/jbc.M109.060418. Epub 2009 Nov 30. J Biol Chem. 2010. PMID: 19948737 Free PMC article.
Activation and specificity of human caspase-10.
Wachmann K, Pop C, van Raam BJ, Drag M, Mace PD, Snipas SJ, Zmasek C, Schwarzenbacher R, Salvesen GS, Riedl SJ. Wachmann K, et al. Among authors: drag m. Biochemistry. 2010 Sep 28;49(38):8307-15. doi: 10.1021/bi100968m. Biochemistry. 2010. PMID: 20795673 Free PMC article.
Emerging principles in protease-based drug discovery.
Drag M, Salvesen GS. Drag M, et al. Nat Rev Drug Discov. 2010 Sep;9(9):690-701. doi: 10.1038/nrd3053. Nat Rev Drug Discov. 2010. PMID: 20811381 Free PMC article. Review.
Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4).
Shu CW, Drag M, Bekes M, Zhai D, Salvesen GS, Reed JC. Shu CW, et al. Among authors: drag m. Autophagy. 2010 Oct;6(7):936-47. doi: 10.4161/auto.6.7.13075. Epub 2010 Oct 19. Autophagy. 2010. PMID: 20818167 Free PMC article.
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