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The role of SATB2 as a diagnostic marker for tumors of colorectal origin: Results of a pathology-based clinical prospective study.
Dragomir A, de Wit M, Johansson C, Uhlen M, Pontén F. Dragomir A, et al. Am J Clin Pathol. 2014 May;141(5):630-8. doi: 10.1309/AJCPWW2URZ9JKQJU. Am J Clin Pathol. 2014. PMID: 24713733
RESULTS: SATB2 showed a high sensitivity (93%) and specificity (77%) to determine a cancer of colorectal origin and in combination with CK7 and CK20, the specificity increased to 100%. CONCLUSIONS: We conclude that SATB2 provides a new and advantageous supple …
RESULTS: SATB2 showed a high sensitivity (93%) and specificity (77%) to determine a cancer of colorectal origin and in combina …
Treatment-related survival associations of claudin-2 expression in fibroblasts of colorectal cancer.
Mezheyeuski A, Strell C, Hrynchyk I, Guren TK, Dragomir A, Doroshenko T, Pashkova O, Gorgun J, Ruksha K, Pfeiffer P, Kure EH, Sorbye H, Edler D, Martling A, Glimelius B, Östman A, Portyanko A. Mezheyeuski A, et al. Virchows Arch. 2018 Mar;472(3):395-405. doi: 10.1007/s00428-017-2263-3. Epub 2017 Nov 13. Virchows Arch. 2018. PMID: 29134439 Free PMC article.
Claudin-2 is a trans-membrane protein-component of tight junctions in epithelial cells. Elevated claudin-2 expression has been reported in colorectal cancer (CRC). ...Claudin-2 IHC staining was evaluated in a semi-quantitative manner in different regions and cell ty …
Claudin-2 is a trans-membrane protein-component of tight junctions in epithelial cells. Elevated claudin-2 expression has been report …
High RBM3 expression is associated with an improved survival and oxaliplatin response in patients with metastatic colorectal cancer.
Siesing C, Sorbye H, Dragomir A, Pfeiffer P, Qvortrup C, Pontén F, Jirström K, Glimelius B, Eberhard J. Siesing C, et al. PLoS One. 2017 Aug 11;12(8):e0182512. doi: 10.1371/journal.pone.0182512. eCollection 2017. PLoS One. 2017. PMID: 28800641 Free PMC article.
The aim of this study was to evaluate RBM3 in metastatic colorectal cancer (mCRC) as a prognostic factor for overall survival and in relation to benefit of first-line chemotherapy. ...
The aim of this study was to evaluate RBM3 in metastatic colorectal cancer (mCRC) as a prognostic factor for overall survival and in …
Tumoral cubilin is a predictive marker for treatment of renal cancer patients with sunitinib and sorafenib.
Niinivirta M, Enblad G, Edqvist PH, Pontén F, Dragomir A, Ullenhag GJ. Niinivirta M, et al. J Cancer Res Clin Oncol. 2017 Jun;143(6):961-970. doi: 10.1007/s00432-017-2365-y. Epub 2017 Mar 4. J Cancer Res Clin Oncol. 2017. PMID: 28260162 Free PMC article.
Cubilin is a membrane protein expressed in the proximal renal tubule. Cubilin and megalin function together as endocytic receptors mediating uptake of many proteins. ...METHODS: Cubilin protein expression was analyzsed in tumor tissue from a cohort of patients with …
Cubilin is a membrane protein expressed in the proximal renal tubule. Cubilin and megalin function together as endocytic receptors me …
Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer.
Mezheyeuski A, Bradic Lindh M, Guren TK, Dragomir A, Pfeiffer P, Kure EH, Ikdahl T, Skovlund E, Corvigno S, Strell C, Pietras K, Ponten F, Mulder J, Qvortrup C, Portyanko A, Tveit KM, Glimelius B, Sorbye H, Östman A. Mezheyeuski A, et al. Oncotarget. 2016 Jul 5;7(27):41948-41958. doi: 10.18632/oncotarget.9632. Oncotarget. 2016. PMID: 27248825 Free PMC article. Clinical Trial.
Perivascular heterogeneity in clinical samples, and associations with other tumor features and outcome, remain largely unknown.Here we report a novel method for digital quantitative analyses of vessel characteristics and PC, which was applied to two collections of human me …
Perivascular heterogeneity in clinical samples, and associations with other tumor features and outcome, remain largely unknown.Here we repor …
High BRAF Mutation Frequency and Marked Survival Differences in Subgroups According to KRAS/BRAF Mutation Status and Tumor Tissue Availability in a Prospective Population-Based Metastatic Colorectal Cancer Cohort.
Sorbye H, Dragomir A, Sundström M, Pfeiffer P, Thunberg U, Bergfors M, Aasebø K, Eide GE, Ponten F, Qvortrup C, Glimelius B. Sorbye H, et al. PLoS One. 2015 Jun 29;10(6):e0131046. doi: 10.1371/journal.pone.0131046. eCollection 2015. PLoS One. 2015. PMID: 26121270 Free PMC article.
Patient characteristics, treatment and efficacy according to KRAS, BRAF and MSI status were analyzed in a prospectively collected unselected population-based cohort of 798 non-resectable mCRC patients. ...The 92 patients (21%) with BRAF mutation had a poor prognosis …
Patient characteristics, treatment and efficacy according to KRAS, BRAF and MSI status were analyzed in a prospectively collected uns …
CFTR and tight junctions in cultured bronchial epithelial cells.
Nilsson HE, Dragomir A, Lazorova L, Johannesson M, Roomans GM. Nilsson HE, et al. Exp Mol Pathol. 2010 Feb;88(1):118-27. doi: 10.1016/j.yexmp.2009.09.018. Epub 2009 Oct 8. Exp Mol Pathol. 2010. PMID: 19818767
Addition of a specific inhibitor of CFTR (CFTR(inh)-172) to 16HBE14o- and CFBE41o-pCep4 cells resulted in a time-dependent increase in TEER, whereas stimulation of CFTR by IBMX and forskolin caused a decrease. ...Immunofluorescence revealed a disorgani …
Addition of a specific inhibitor of CFTR (CFTR(inh)-172) to 16HBE14o- and CFBE41o-pCep4 cells resulted in a time-dependent inc …
The effect of S-nitrosoglutathione and L-cysteine on chloride efflux from cystic fibrosis airway epithelial cells.
Servetnyk Z, Jiang S, Hjelte L, Gaston B, Roomans GM, Dragomir A. Servetnyk Z, et al. Exp Mol Pathol. 2011 Feb;90(1):79-83. doi: 10.1016/j.yexmp.2010.10.005. Epub 2010 Oct 19. Exp Mol Pathol. 2011. PMID: 20965165
The endogenous bronchodilator, S-nitrosoglutathione (GSNO), has been proposed as a possible pharmacological remedy that reverses the ΔF508-CFTR (cystic fibrosis transmembrane conductance regulator) maturation defect and increases CFTR-mediated chloride efflux in cultured c …
The endogenous bronchodilator, S-nitrosoglutathione (GSNO), has been proposed as a possible pharmacological remedy that reverses the …
Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients.
Aasebø KØ, Dragomir A, Sundström M, Mezheyeuski A, Edqvist PH, Eide GE, Ponten F, Pfeiffer P, Glimelius B, Sorbye H. Aasebø KØ, et al. Cancer Med. 2019 Jul;8(7):3623-3635. doi: 10.1002/cam4.2205. Epub 2019 May 9. Cancer Med. 2019. PMID: 31070306 Free PMC article.
METHODS: A population-based cohort of 798 mCRC patients in Scandinavia was studied. Patient and molecular tumor characteristics, overall survival (OS) and progression-free survival (PFS) were estimated. ...
METHODS: A population-based cohort of 798 mCRC patients in Scandinavia was studied. Patient and molecular tumor characteristics, over …
Effects of nicotine on intestinal epithelial cells in vivo and in vitro: an X-ray microanalytical study.
Kozlova I, Dragomir A, Vanthanouvong V, Roomans GM. Kozlova I, et al. J Submicrosc Cytol Pathol. 2000 Jan;32(1):97-102. J Submicrosc Cytol Pathol. 2000. PMID: 10877107
It has been suggested that nicotine may have a beneficial effect on ulcerative colitis. Little is known, however, about the mechanism of such an effect. ...The results may indicate a disturbance of fluid transport in the intestine by nicotine. Possible mechanisms, s …
It has been suggested that nicotine may have a beneficial effect on ulcerative colitis. Little is known, however, about the mechanism …
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