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Different mechanisms regulate IPSC kinetics in early postnatal and juvenile hippocampal granule cells.
Draguhn A, Heinemann U. Draguhn A, et al. J Neurophysiol. 1996 Dec;76(6):3983-93. doi: 10.1152/jn.1996.76.6.3983. J Neurophysiol. 1996. PMID: 8985894
The focally evoked currents were mediated by gamma-aminobutyric acid-A (GABAA) receptors. 2. IPSCs were characterized by a steep rising phase and a slower, monoexponential decay time course. The decay time constant was potential dependent and average values r …
The focally evoked currents were mediated by gamma-aminobutyric acid-A (GABAA) receptors. 2. IPSCs were characterized by a ste …
Different functions of hyperpolarization-activated cation channels for hippocampal sharp waves and ripples in vitro.
Kranig SA, Duhme N, Waldeck C, Draguhn A, Reichinnek S, Both M. Kranig SA, et al. Neuroscience. 2013 Jan 3;228:325-33. doi: 10.1016/j.neuroscience.2012.10.050. Epub 2012 Nov 2. Neuroscience. 2013. PMID: 23123919
Consistently, I(h) plays a key role for oscillations at the cellular and network level, including theta and gamma oscillations in rodent hippocampal circuits. ...Control experiments exclude a contribution of T-type calcium channels to the observed effects. Together, …
Consistently, I(h) plays a key role for oscillations at the cellular and network level, including theta and gamma oscillations in rod …
Plasticity of rat central inhibitory synapses through GABA metabolism.
Engel D, Pahner I, Schulze K, Frahm C, Jarry H, Ahnert-Hilger G, Draguhn A. Engel D, et al. J Physiol. 2001 Sep 1;535(Pt 2):473-82. doi: 10.1111/j.1469-7793.2001.00473.x. J Physiol. 2001. PMID: 11533137 Free PMC article.
It therefore seems possible that GABA metabolism can determine inhibitory synaptic strength and that presynaptic GABA content is a regulated parameter for synaptic plasticity. 2. ...Our data reveal a new mechanism of plasticity at central inhibitory synapses and pro …
It therefore seems possible that GABA metabolism can determine inhibitory synaptic strength and that presynaptic GABA content is a re …
Region- and pattern-specific effects of glutamate uptake blockers on epileptiform activity in rat brain slices.
Bertsche A, Bruehl C, Pietz J, Draguhn A. Bertsche A, et al. Epilepsy Res. 2010 Feb;88(2-3):118-26. doi: 10.1016/j.eplepsyres.2009.10.006. Epub 2009 Nov 24. Epilepsy Res. 2010. PMID: 19939631
The transmitter glutamate serves a double role as excitatory transmitter and as precursor for GABA, thus interfering with glutamate uptake may therefore exert complex effects on excitation-inhibition-balance in epileptic networks. ...Three different models were used to ind …
The transmitter glutamate serves a double role as excitatory transmitter and as precursor for GABA, thus interfering with glutamate u …
A simple hardware model for the direct observation of voltage-clamp performance under realistic conditions.
Draguhn A, Pfeiffer M, Heinemann U, Polder R. Draguhn A, et al. J Neurosci Methods. 1997 Dec 30;78(1-2):105-13. doi: 10.1016/s0165-0270(97)00138-6. J Neurosci Methods. 1997. PMID: 9497006
Each compartment consists of a capacitor in parallel with a variable resistor and can be connected to other compartments by a variable axial resistance. ...The cell model is a new and easy-to-handle tool for the observation of voltage control under rea …
Each compartment consists of a capacitor in parallel with a variable resistor and can be connected to other compartments by …
Acute effects of gamma-vinyl-GABA on low-magnesium evoked epileptiform activity in vitro.
Engel D, Endermann U, Frahm C, Heinemann U, Draguhn A. Engel D, et al. Epilepsy Res. 2000 Jul;40(2-3):99-107. doi: 10.1016/s0920-1211(00)00112-1. Epilepsy Res. 2000. PMID: 10863137
Vigabatrin (gamma-vinyl-GABA, VGB) is a gamma-aminobutyric acid (GABA) derivative designed to boost synaptic inhibition by inhibiting the degradation of GABA in brain tissue. ...VGB at 100 microM-5 mM showed a concentration- and time-dependent reduction of intericta …
Vigabatrin (gamma-vinyl-GABA, VGB) is a gamma-aminobutyric acid (GABA) derivative designed to boost synaptic inhibition by inhibiting …
Expression of Kv1 potassium channels in mouse hippocampal primary cultures: development and activity-dependent regulation.
Grosse G, Draguhn A, Höhne L, Tapp R, Veh RW, Ahnert-Hilger G. Grosse G, et al. J Neurosci. 2000 Mar 1;20(5):1869-82. doi: 10.1523/JNEUROSCI.20-05-01869.2000. J Neurosci. 2000. PMID: 10684888 Free PMC article.
This developmental upregulation was paralleled by a dramatic increase in total K(+) current, as well as an elevated GABA release in the presence of 4-aminopyridine. ...Our data show that hippocampal neurons in culture are a convenient model to study the developmenta …
This developmental upregulation was paralleled by a dramatic increase in total K(+) current, as well as an elevated GABA release in t …
Sodium bromide: effects on different patterns of epileptiform activity, extracellular pH changes and GABAergic inhibition.
Meierkord H, Grünig F, Gutschmidt U, Gutierrez R, Pfeiffer M, Draguhn A, Brückner C, Heinemann U. Meierkord H, et al. Naunyn Schmiedebergs Arch Pharmacol. 2000 Jan;361(1):25-32. doi: 10.1007/s002109900162. Naunyn Schmiedebergs Arch Pharmacol. 2000. PMID: 10651143
Acetazolamide at 1 mM caused a reversible acidification of delta pH: 0.2+/-0.14 at rest whereas no change on extracellular pH was seen with 5 mM NaBr. ...A significant increase in paired-pulse inhibition was seen in a paired-pulse stimulation protocol used to …
Acetazolamide at 1 mM caused a reversible acidification of delta pH: 0.2+/-0.14 at rest whereas no change on extracellular pH was see …
Age-dependence of the anticonvulsant effects of the GABA uptake inhibitor tiagabine in vitro.
Sabau A, Frahm C, Pfeiffer M, Breustedt J, Piechotta A, Numberger M, Engel D, Heinemann U, Draguhn A. Sabau A, et al. Eur J Pharmacol. 1999 Nov 3;383(3):259-66. doi: 10.1016/s0014-2999(99)00628-7. Eur J Pharmacol. 1999. PMID: 10594317
Large-conductance cation channels in the envelope of nuclei from rat cerebral cortex.
Draguhn A, Börner G, Beckmann R, Buchner K, Heinemann U, Hucho F. Draguhn A, et al. J Membr Biol. 1997 Jul 15;158(2):159-66. doi: 10.1007/s002329900253. J Membr Biol. 1997. PMID: 9230093
Eucaryotic nuclei are surrounded by a double-membrane system enclosing a central cisterna which is continuous with the endoplasmic reticulum and serves as a calcium store for intracellular signaling. ...Surprisingly, patch clamp recordings from isolated nucle …
Eucaryotic nuclei are surrounded by a double-membrane system enclosing a central cisterna which is continuous with the endopla …
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