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Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary parenteral glutathione in preclinical cancer models.
Chen P, Stone J, Sullivan G, Drisko JA, Chen Q. Chen P, et al. Among authors: drisko ja. Free Radic Biol Med. 2011 Aug 1;51(3):681-7. doi: 10.1016/j.freeradbiomed.2011.05.031. Epub 2011 May 30. Free Radic Biol Med. 2011. PMID: 21672627
Effect of high-dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT).
Issa OM, Roberts R, Mark DB, Boineau R, Goertz C, Rosenberg Y, Lewis EF, Guarneri E, Drisko J, Magaziner A, Lee KL, Lamas GA. Issa OM, et al. Among authors: drisko j. Am Heart J. 2018 Jan;195:70-77. doi: 10.1016/j.ahj.2017.09.002. Epub 2017 Sep 8. Am Heart J. 2018. PMID: 29224648 Clinical Trial.
EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy.
Lamas GA, Boineau R, Goertz C, Mark DB, Rosenberg Y, Stylianou M, Rozema T, Nahin RL, Terry Chappell L, Lindblad L, Lewis EF, Drisko J, Lee KL. Lamas GA, et al. Among authors: drisko j. Am Heart J. 2014 Jul;168(1):37-44.e5. doi: 10.1016/j.ahj.2014.02.012. Epub 2014 Apr 2. Am Heart J. 2014. PMID: 24952858 Free PMC article. Clinical Trial.
Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial.
Welsh JL, Wagner BA, van't Erve TJ, Zehr PS, Berg DJ, Halfdanarson TR, Yee NS, Bodeker KL, Du J, Roberts LJ 2nd, Drisko J, Levine M, Buettner GR, Cullen JJ. Welsh JL, et al. Among authors: drisko j. Cancer Chemother Pharmacol. 2013 Mar;71(3):765-75. doi: 10.1007/s00280-013-2070-8. Epub 2013 Feb 5. Cancer Chemother Pharmacol. 2013. PMID: 23381814 Free PMC article. Clinical Trial.
Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer.
Espey MG, Chen P, Chalmers B, Drisko J, Sun AY, Levine M, Chen Q. Espey MG, et al. Among authors: drisko j. Free Radic Biol Med. 2011 Jun 1;50(11):1610-9. doi: 10.1016/j.freeradbiomed.2011.03.007. Epub 2011 Mar 12. Free Radic Biol Med. 2011. PMID: 21402145 Free PMC article.
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.
Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M. Chen Q, et al. Among authors: drisko j. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11105-9. doi: 10.1073/pnas.0804226105. Epub 2008 Aug 4. Proc Natl Acad Sci U S A. 2008. PMID: 18678913 Free PMC article. Clinical Trial.
Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy.
Chen P, Yu J, Chalmers B, Drisko J, Yang J, Li B, Chen Q. Chen P, et al. Among authors: drisko j. Anticancer Drugs. 2012 Apr;23(4):437-44. doi: 10.1097/CAD.0b013e32834fd01f. Anticancer Drugs. 2012. PMID: 22205155
High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy.
Ma Y, Chapman J, Levine M, Polireddy K, Drisko J, Chen Q. Ma Y, et al. Among authors: drisko j. Sci Transl Med. 2014 Feb 5;6(222):222ra18. doi: 10.1126/scitranslmed.3007154. Sci Transl Med. 2014. PMID: 24500406 Clinical Trial.
Inhibition of pancreatic cancer and potentiation of gemcitabine effects by the extract of Pao Pereira.
Yu J, Drisko J, Chen Q. Yu J, et al. Among authors: drisko j. Oncol Rep. 2013 Jul;30(1):149-56. doi: 10.3892/or.2013.2461. Epub 2013 May 14. Oncol Rep. 2013. PMID: 23674070
Antitumor Activities of Rauwolfia vomitoria Extract and Potentiation of Carboplatin Effects Against Ovarian Cancer.
Yu J, Ma Y, Drisko J, Chen Q. Yu J, et al. Among authors: drisko j. Curr Ther Res Clin Exp. 2013 Dec;75:8-14. doi: 10.1016/j.curtheres.2013.04.001. Curr Ther Res Clin Exp. 2013. PMID: 24465036 Free PMC article.
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