Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 19
1964 54
1965 44
1966 62
1967 175
1968 310
1969 461
1970 522
1971 653
1972 737
1973 848
1974 944
1975 873
1976 853
1977 795
1978 952
1979 1020
1980 1101
1981 1127
1982 1386
1983 1649
1984 1899
1985 2042
1986 2014
1987 2361
1988 3059
1989 3956
1990 4606
1991 4612
1992 4891
1993 5492
1994 5758
1995 6065
1996 6571
1997 6882
1998 7501
1999 8167
2000 9479
2001 10609
2002 11907
2003 13017
2004 14038
2005 14607
2006 15846
2007 16626
2008 17214
2009 17662
2010 18959
2011 20252
2012 21579
2013 22039
2014 23073
2015 23405
2016 24018
2017 24101
2018 23544
2019 23034
2020 26986
2021 27473
2022 21836
2023 16560
2024 162

Text availability

Article attribute

Article type

Publication date

Search Results

502,060 results

Results by year

Filters applied: . Clear all
Page 1
Cytochrome P450 Enzymes and Drug Metabolism in Humans.
Zhao M, Ma J, Li M, Zhang Y, Jiang B, Zhao X, Huai C, Shen L, Zhang N, He L, Qin S. Zhao M, et al. Int J Mol Sci. 2021 Nov 26;22(23):12808. doi: 10.3390/ijms222312808. Int J Mol Sci. 2021. PMID: 34884615 Free PMC article. Review.
In addition to the basic metabolic effects for elimination, CYPs are also capable of affecting drug responses by influencing drug action, safety, bioavailability, and drug resistance through metabolism, in both metabolic organs and …
In addition to the basic metabolic effects for elimination, CYPs are also capable of affecting drug responses by influe …
Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters.
Cobbina E, Akhlaghi F. Cobbina E, et al. Drug Metab Rev. 2017 May;49(2):197-211. doi: 10.1080/03602532.2017.1293683. Epub 2017 Mar 17. Drug Metab Rev. 2017. PMID: 28303724 Free PMC article. Review.
These factors may result in altered expression and activity of drug metabolizing enzymes (DMEs) or transporters. Existing evidence suggests that the effect of NAFLD on CYP3A4, CYP2E1 and MRP3 is more consistent across rodent and human studies. ...The alterations ass …
These factors may result in altered expression and activity of drug metabolizing enzymes (DMEs) or transporters. Existing evid …
Regulation and metabolic functions of mTORC1 and mTORC2.
Szwed A, Kim E, Jacinto E. Szwed A, et al. Physiol Rev. 2021 Jul 1;101(3):1371-1426. doi: 10.1152/physrev.00026.2020. Epub 2021 Feb 18. Physiol Rev. 2021. PMID: 33599151 Free PMC article. Review.
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the environment and their intracellular metabolism is a highly controlled process that involves cross talk between growth signaling and …
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the …
Drug Metabolism in the Liver.
Almazroo OA, Miah MK, Venkataramanan R. Almazroo OA, et al. Clin Liver Dis. 2017 Feb;21(1):1-20. doi: 10.1016/j.cld.2016.08.001. Epub 2016 Oct 15. Clin Liver Dis. 2017. PMID: 27842765 Review.
Phase II drug metabolism is a conjugation reaction. Phase III refers to transporter-mediated elimination of drug and/or metabolites from body normally via liver, gut, kidney, or lung. This review presents basic information on drug-metabolizing e …
Phase II drug metabolism is a conjugation reaction. Phase III refers to transporter-mediated elimination of drug and/or …
NRF2, a Transcription Factor for Stress Response and Beyond.
He F, Ru X, Wen T. He F, et al. Int J Mol Sci. 2020 Jul 6;21(13):4777. doi: 10.3390/ijms21134777. Int J Mol Sci. 2020. PMID: 32640524 Free PMC article. Review.
In addition to antioxidant responses, NRF2 is involved in many other cellular processes, including metabolism and inflammation, and its functions are beyond the originally envisioned. ...Here we summarize the complex regulatory network of NRF2 activity and its roles …
In addition to antioxidant responses, NRF2 is involved in many other cellular processes, including metabolism and inflammation …
Developmental Changes in Pharmacokinetics and Pharmacodynamics.
van den Anker J, Reed MD, Allegaert K, Kearns GL. van den Anker J, et al. J Clin Pharmacol. 2018 Oct;58 Suppl 10:S10-S25. doi: 10.1002/jcph.1284. J Clin Pharmacol. 2018. PMID: 30248190 Review.
Effective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. ...What is known about the influence of maturation on the processes of drug absorption, distr …
Effective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, …
Adipocyte and lipid metabolism in cancer drug resistance.
Cao Y. Cao Y. J Clin Invest. 2019 Jul 2;129(8):3006-3017. doi: 10.1172/JCI127201. eCollection 2019 Jul 2. J Clin Invest. 2019. PMID: 31264969 Free PMC article. Review.
While cancer cells' dependence on glycolysis for energy production is well studied, the roles of adipocytes and lipid metabolic reprogramming in supporting cancer growth, metastasis, and drug responses are less understood. This Review focuses on emerging mech …
While cancer cells' dependence on glycolysis for energy production is well studied, the roles of adipocytes and lipid metabolic repro …
Effects of infant formula composition on long-term metabolic health.
Lemaire M, Le Huërou-Luron I, Blat S. Lemaire M, et al. J Dev Orig Health Dis. 2018 Dec;9(6):573-589. doi: 10.1017/S2040174417000964. Epub 2018 Feb 5. J Dev Orig Health Dis. 2018. PMID: 29397805 Free article. Review.
Early nutrition may have long-lasting metabolic impacts in adulthood. Even though breast milk is the gold standard, most infants are at least partly formula-fed. ...Improvements such as reducing the protein content, modulating the lipid matrix and adding prebiotics, probio …
Early nutrition may have long-lasting metabolic impacts in adulthood. Even though breast milk is the gold standard, most infants are …
L-carnitine--metabolic functions and meaning in humans life.
Pekala J, Patkowska-Sokoła B, Bodkowski R, Jamroz D, Nowakowski P, Lochyński S, Librowski T. Pekala J, et al. Curr Drug Metab. 2011 Sep;12(7):667-78. doi: 10.2174/138920011796504536. Curr Drug Metab. 2011. PMID: 21561431 Review.
L-Carnitine is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-lysine and L-methionine, as substrates. ...Further research is warranted in order to evaluate the biochemical, pharmacological, and physiologi …
L-Carnitine is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-ly …
Metabolic reprogramming in triple-negative breast cancer.
Wang Z, Jiang Q, Dong C. Wang Z, et al. Cancer Biol Med. 2020 Feb 15;17(1):44-59. doi: 10.20892/j.issn.2095-3941.2019.0210. Cancer Biol Med. 2020. PMID: 32296576 Free PMC article. Review.
Understanding the mechanisms of metabolic remodeling may guide the design of metabolic strategies for the effective intervention of TNBC. Here, we review the metabolic reprogramming of glycolysis, oxidative phosphorylation, amino acid metabolism, lipid …
Understanding the mechanisms of metabolic remodeling may guide the design of metabolic strategies for the effective interventi …
502,060 results
You have reached the last available page of results. Please see the User Guide for more information.