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10,176 results

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Page 1
Showing results for drug induced hyperlipidemia
Search for Drug-induced hyperlipasemia instead (3 results)
alpha-Ketoglutarate prevents hyperlipidemia-induced fatty liver mitochondrial dysfunction and oxidative stress by activating the AMPK-pgc-1alpha/Nrf2 pathway.
Cheng D, Zhang M, Zheng Y, Wang M, Gao Y, Wang X, Liu X, Lv W, Zeng X, Belosludtsev KN, Su J, Zhao L, Liu J. Cheng D, et al. Redox Biol. 2024 Aug;74:103230. doi: 10.1016/j.redox.2024.103230. Epub 2024 Jun 13. Redox Biol. 2024. PMID: 38875959 Free PMC article.
alpha-Ketoglutarate (AKG), a crucial intermediate in the tricarboxylic acid cycle, has been demonstrated to mitigate hyperlipidemia-induced dyslipidemia and endothelial damage. While hyperlipidemia stands as a major trigger for non-alcoholic fatty liver disea …
alpha-Ketoglutarate (AKG), a crucial intermediate in the tricarboxylic acid cycle, has been demonstrated to mitigate hyperlipidemia- …
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.
Zheng ZG, Zhu ST, Cheng HM, Zhang X, Cheng G, Thu PM, Wang SP, Li HJ, Ding M, Qiang L, Chen XW, Zhong Q, Li P, Xu X. Zheng ZG, et al. Autophagy. 2021 Jul;17(7):1592-1613. doi: 10.1080/15548627.2020.1757955. Epub 2020 May 20. Autophagy. 2021. PMID: 32432943 Free PMC article.
SCAP (SREBF chaperone) regulates SREBFs (sterol regulatory element binding transcription factors) processing and stability, and, thus, becomes an emerging drug target to treat dyslipidemia and fatty liver disease. However, the current known SCAP inhibitors, such as oxyster …
SCAP (SREBF chaperone) regulates SREBFs (sterol regulatory element binding transcription factors) processing and stability, and, thus, becom …
Probiotics for the treatment of hyperlipidemia: Focus on gut-liver axis and lipid metabolism.
You M, Zhou L, Wu F, Zhang L, Zhu SX, Zhang HX. You M, et al. Pharmacol Res. 2025 Apr;214:107694. doi: 10.1016/j.phrs.2025.107694. Epub 2025 Mar 10. Pharmacol Res. 2025. PMID: 40068270 Free article. Review.
Available evidence suggests that high-fat diet-induced the gut microbiota dysbiosis can induce "leaky gut," allowing toxic microbial metabolites to enter the liver via portal circulation, triggering liver inflammation and lipid metabolism disturbances, ultimately le …
Available evidence suggests that high-fat diet-induced the gut microbiota dysbiosis can induce "leaky gut," allowing toxic mic …
A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis.
Wang WZ, Liu C, Luo JQ, Lei LJ, Chen MH, Zhang YY, Sheng R, Li YN, Wang L, Jiang XH, Xiao TM, Zhang YH, Li SW, Wu YX, Xu Y, Xu YN, Si SY. Wang WZ, et al. Acta Pharmacol Sin. 2024 Oct;45(10):2119-2133. doi: 10.1038/s41401-024-01305-9. Epub 2024 May 29. Acta Pharmacol Sin. 2024. PMID: 38811775 Free PMC article.
We revealed that E28362 selectively bound to PCSK9 in HepG2 and AML12 cells, blocked the interaction between LDLR and PCSK9, and induced the degradation of PCSK9 through the ubiquitin-proteasome pathway, which finally resulted in increased LDLR protein levels. In conclusio …
We revealed that E28362 selectively bound to PCSK9 in HepG2 and AML12 cells, blocked the interaction between LDLR and PCSK9, and induced …
Atorvastatin Ester Regulates Lipid Metabolism in Hyperlipidemia Rats via the PPAR-signaling Pathway and HMGCR Expression in the Liver.
Hu N, Chen C, Wang J, Huang J, Yao D, Li C. Hu N, et al. Int J Mol Sci. 2021 Oct 14;22(20):11107. doi: 10.3390/ijms222011107. Int J Mol Sci. 2021. PMID: 34681767 Free PMC article.
Male Sprague Dawley (SD) rats were fed a high-fat diet for seven months and used as a hyperlipidemia model. The lipid level and liver function of the hyperlipidemia rats were studied by the levels of TG, TC, LDL, HDL, ALT, and AST in serum after intragastric adminis …
Male Sprague Dawley (SD) rats were fed a high-fat diet for seven months and used as a hyperlipidemia model. The lipid level and liver …
Protective effect of bromelain on some metabolic enzyme activities in tyloxapol-induced hyperlipidemic rats.
Sulumer AN, Palabıyık E, Avcı B, Uguz H, Demir Y, Serhat Özaslan M, Aşkın H. Sulumer AN, et al. Biotechnol Appl Biochem. 2024 Feb;71(1):17-27. doi: 10.1002/bab.2517. Epub 2023 Sep 25. Biotechnol Appl Biochem. 2024. PMID: 37749825
Hence, the purpose of this study was to determine the possible protective impact of bromelain on some metabolic enzymes (paraoxonase-1, glutathione S-transferase, glutathione reductase, sorbitol dehydrogenase [SDH], aldose reductase [AR], butyrylcholinesterase [BChE], and acetylc …
Hence, the purpose of this study was to determine the possible protective impact of bromelain on some metabolic enzymes (paraoxonase-1, glut …
Tumor-Induced Hyperlipidemia Contributes to Tumor Growth.
Huang J, Li L, Lian J, Schauer S, Vesely PW, Kratky D, Hoefler G, Lehner R. Huang J, et al. Cell Rep. 2016 Apr 12;15(2):336-48. doi: 10.1016/j.celrep.2016.03.020. Epub 2016 Mar 31. Cell Rep. 2016. PMID: 27050512 Free PMC article.
BCR-Abl-transformed precursor B cell tumors induced hyperlipidemia by stimulating very low-density lipoprotein (VLDL) production and blunting VLDL and low-density lipoprotein (LDL) turnover. To assess whether tumor progression was dependent on tumor-induced …
BCR-Abl-transformed precursor B cell tumors induced hyperlipidemia by stimulating very low-density lipoprotein (VLDL) producti …
alpha-Ketoglutarate Attenuates Hyperlipidemia-Induced Endothelial Damage by Activating the Erk-Nrf2 Signaling Pathway to Inhibit Oxidative Stress and Mitochondrial Dysfunction.
Cheng D, Liu X, Gao Y, Cui L, Wang M, Zheng Y, Lv W, Zhao L, Liu J. Cheng D, et al. Antioxid Redox Signal. 2023 Oct;39(10-12):777-793. doi: 10.1089/ars.2022.0215. Antioxid Redox Signal. 2023. PMID: 37154729
Innovation: These results reveal the role of the AKG-ERK-Nrf2 signaling pathway in the prevention of hyperlipidemia-induced endothelial damage, and suggest that AKG, as a mitochondria-targeting nutrient, is a potential drug for the treatment of endothelial da …
Innovation: These results reveal the role of the AKG-ERK-Nrf2 signaling pathway in the prevention of hyperlipidemia-induced en …
Oleoylethanolamide alleviates hyperlipidaemia-mediated vascular calcification via attenuating mitochondrial DNA stress triggered autophagy-dependent ferroptosis by activating PPARalpha.
Chen Z, Sun X, Li X, Liu N. Chen Z, et al. Biochem Pharmacol. 2023 Feb;208:115379. doi: 10.1016/j.bcp.2022.115379. Epub 2022 Dec 13. Biochem Pharmacol. 2023. PMID: 36525991
Ferroptosis, a newly iron-dependent programmed cell death, induced by palmitic acid (PA), the major saturated free fatty acid in hyperlipidemia, is a vital mechanism of vascular calcification. ...The calcium deposition in hyperlipidaemia-mediated rat thoracic …
Ferroptosis, a newly iron-dependent programmed cell death, induced by palmitic acid (PA), the major saturated free fatty acid in h …
Protective role of thymoquinone in hyperlipidemia-induced liver injury in LDL-R(-/-)mice.
Wang F, Yao W, Yu D, Hao Y, Wu Y, Zhang X. Wang F, et al. BMC Gastroenterol. 2023 Aug 11;23(1):276. doi: 10.1186/s12876-023-02895-0. BMC Gastroenterol. 2023. PMID: 37568105 Free PMC article.
RESULTS: Our results demonstrated that Thymoquinone administration significantly reduced liver histological alterations by hyperlipidemia. Thymoquinone mitigated hyperlipidemia-induced liver injury as indicated by the suppression of metabolic characteristics, …
RESULTS: Our results demonstrated that Thymoquinone administration significantly reduced liver histological alterations by hyperlipidemia …
10,176 results
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