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TNF-alpha induces two distinct caspase-8 activation pathways.
Wang L, Du F, Wang X. Wang L, et al. Cell. 2008 May 16;133(4):693-703. doi: 10.1016/j.cell.2008.03.036. Cell. 2008. PMID: 18485876
Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK.
Shang L, Chen S, Du F, Li S, Zhao L, Wang X. Shang L, et al. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4788-93. doi: 10.1073/pnas.1100844108. Epub 2011 Mar 7. Proc Natl Acad Sci U S A. 2011. PMID: 21383122 Free PMC article.
Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation.
Rand TA, Petersen S, Du F, Wang X. Rand TA, et al. Cell. 2005 Nov 18;123(4):621-9. doi: 10.1016/j.cell.2005.10.020. Epub 2005 Nov 3. Cell. 2005. PMID: 16271385
Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1.
Kim HE, Du F, Fang M, Wang X. Kim HE, et al. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17545-50. doi: 10.1073/pnas.0507900102. Epub 2005 Oct 26. Proc Natl Acad Sci U S A. 2005. PMID: 16251271 Free PMC article.
The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop.
Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, Brautigam CA, Zhang X, Chen ZJ. Zhang X, et al. Cell Rep. 2014 Feb 13;6(3):421-30. doi: 10.1016/j.celrep.2014.01.003. Epub 2014 Jan 23. Cell Rep. 2014. PMID: 24462292 Free PMC article.
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