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Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.
Muller AJ, DuHadaway JB, Donover PS, Sutanto-Ward E, Prendergast GC. Muller AJ, et al. Among authors: duhadaway jb. Nat Med. 2005 Mar;11(3):312-9. doi: 10.1038/nm1196. Epub 2005 Feb 13. Nat Med. 2005. PMID: 15711557
Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing.
Wechsler-Reya R, Sakamuro D, Zhang J, Duhadaway J, Prendergast GC. Wechsler-Reya R, et al. J Biol Chem. 1997 Dec 12;272(50):31453-8. doi: 10.1074/jbc.272.50.31453. J Biol Chem. 1997. PMID: 9395479
The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2.
Mao NC, Steingrimsson E, DuHadaway J, Wasserman W, Ruiz JC, Copeland NG, Jenkins NA, Prendergast GC. Mao NC, et al. Genomics. 1999 Feb 15;56(1):51-8. doi: 10.1006/geno.1998.5709. Genomics. 1999. PMID: 10036185
Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma.
Ge K, Minhas F, Duhadaway J, Mao NC, Wilson D, Buccafusca R, Sakamuro D, Nelson P, Malkowicz SB, Tomaszewski J, Prendergast GC. Ge K, et al. Int J Cancer. 2000 Apr 15;86(2):155-61. doi: 10.1002/(sici)1097-0215(20000415)86:2<155::aid-ijc2>3.0.co;2-m. Int J Cancer. 2000. PMID: 10738240
Bin1 mediates apoptosis by c-Myc in transformed primary cells.
DuHadaway JB, Sakamuro D, Ewert DL, Prendergast GC. DuHadaway JB, et al. Cancer Res. 2001 Apr 1;61(7):3151-6. Cancer Res. 2001. PMID: 11306501
Immunohistochemical analysis of Bin1/Amphiphysin II in human tissues: diverse sites of nuclear expression and losses in prostate cancer.
DuHadaway JB, Lynch FJ, Brisbay S, Bueso-Ramos C, Troncoso P, McDonnell T, Prendergast GC. DuHadaway JB, et al. J Cell Biochem. 2003 Feb 15;88(3):635-42. doi: 10.1002/jcb.10380. J Cell Biochem. 2003. PMID: 12532338
Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1.
DuHadaway JB, Du W, Donover S, Baker J, Liu AX, Sharp DM, Muller AJ, Prendergast GC. DuHadaway JB, et al. Oncogene. 2003 Jun 5;22(23):3578-88. doi: 10.1038/sj.onc.1206481. Oncogene. 2003. PMID: 12789266
Cyclin B1 is a critical target of RhoB in the cell suicide program triggered by farnesyl transferase inhibition.
Kamasani U, Huang M, Duhadaway JB, Prochownik EV, Donover PS, Prendergast GC. Kamasani U, et al. Among authors: duhadaway jb. Cancer Res. 2004 Nov 15;64(22):8389-96. doi: 10.1158/0008-5472.CAN-04-2437. Cancer Res. 2004. PMID: 15548709
Targeted deletion of the suppressor gene bin1/amphiphysin2 accentuates the neoplastic character of transformed mouse fibroblasts.
Muller AJ, DuHadaway JB, Donover PS, Sutanto-Ward E, Prendergast GC. Muller AJ, et al. Among authors: duhadaway jb. Cancer Biol Ther. 2004 Dec;3(12):1236-42. doi: 10.4161/cbt.3.12.1232. Epub 2004 Dec 14. Cancer Biol Ther. 2004. PMID: 15611650
Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors.
Gaspari P, Banerjee T, Malachowski WP, Muller AJ, Prendergast GC, DuHadaway J, Bennett S, Donovan AM. Gaspari P, et al. J Med Chem. 2006 Jan 26;49(2):684-92. doi: 10.1021/jm0508888. J Med Chem. 2006. PMID: 16420054 Free PMC article.
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