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Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion.
Gao S, Duan X, Wang X, Dong D, Liu D, Li X, Sun G, Li B. Gao S, et al. Among authors: Duan X. Food Chem Toxicol. 2013 Sep;59:739-47. doi: 10.1016/j.fct.2013.07.032. Epub 2013 Jul 18. Food Chem Toxicol. 2013. PMID: 23871787
Tert-butylhydroquinone as a phenolic activator of Nrf2 antagonizes arsenic-induced oxidative cytotoxicity but promotes arsenic methylation and detoxication in human hepatocyte cell line.
Duan X, Liu D, Xing X, Li J, Zhao S, Nie H, Zhang Y, Sun G, Li B. Duan X, et al. Biol Trace Elem Res. 2014 Aug;160(2):294-302. doi: 10.1007/s12011-014-0042-4. Epub 2014 Jun 28. Biol Trace Elem Res. 2014. PMID: 24970285
Antioxidant tert-butylhydroquinone ameliorates arsenic-induced intracellular damages and apoptosis through induction of Nrf2-dependent antioxidant responses as well as stabilization of anti-apoptotic factor Bcl-2 in human keratinocytes.
Duan X, Li J, Li W, Xing X, Zhang Y, Li W, Zhao L, Sun G, Gao XH, Li B. Duan X, et al. Free Radic Biol Med. 2016 May;94:74-87. doi: 10.1016/j.freeradbiomed.2016.02.009. Epub 2016 Feb 12. Free Radic Biol Med. 2016. PMID: 26878773
More interestingly, arsenic-induced decrease of anti-apoptotic factor B-cell lymphoma-2 (Bcl-2) and increase of pro-apoptotic factor Bcl-2-associated X protein (Bax) could all be reversed by tBHQ pretreatment. ...
More interestingly, arsenic-induced decrease of anti-apoptotic factor B-cell lymphoma-2 (Bcl-2) and increase of pro-apoptotic factor Bcl-2-a …
Tissue-specific distributions of inorganic arsenic and its methylated metabolites, especially in cerebral cortex, cerebellum and hippocampus of mice after a single oral administration of arsenite.
Li J, Duan X, Dong D, Zhang Y, Zhao L, Li W, Chen J, Sun G, Li B. Li J, et al. Among authors: Duan X. J Trace Elem Med Biol. 2017 Sep;43:15-22. doi: 10.1016/j.jtemb.2016.10.002. Epub 2016 Oct 4. J Trace Elem Med Biol. 2017. PMID: 27745987
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