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Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors.
Duarte CD, Tributino JL, Lacerda DI, Martins MV, Alexandre-Moreira MS, Dutra F, Bechara EJ, De-Paula FS, Goulart MO, Ferreira J, Calixto JB, Nunes MP, Bertho AL, Miranda AL, Barreiro EJ, Fraga CA. Duarte CD, et al. Bioorg Med Chem. 2007 Mar 15;15(6):2421-33. doi: 10.1016/j.bmc.2007.01.013. Epub 2007 Jan 17. Bioorg Med Chem. 2007. PMID: 17275312
LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation.
Tributino JL, Santos ML, Mesquita CM, Lima CK, Silva LL, Maia RC, Duarte CD, Barreiro EJ, Fraga CA, Castro NG, Miranda AL, Guimaraes MZ. Tributino JL, et al. Among authors: duarte cd. Br J Pharmacol. 2010 Apr;159(8):1716-23. doi: 10.1111/j.1476-5381.2010.00672.x. Br J Pharmacol. 2010. PMID: 20401963 Free PMC article.
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