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Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.
Schwaeble WJ, Lynch NJ, Clark JE, Marber M, Samani NJ, Ali YM, Dudler T, Parent B, Lhotta K, Wallis R, Farrar CA, Sacks S, Lee H, Zhang M, Iwaki D, Takahashi M, Fujita T, Tedford CE, Stover CM. Schwaeble WJ, et al. Among authors: dudler t. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7523-8. doi: 10.1073/pnas.1101748108. Epub 2011 Apr 18. Proc Natl Acad Sci U S A. 2011. PMID: 21502512 Free PMC article.
The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.
Ali YM, Lynch NJ, Haleem KS, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, Girija UV, Wallis R, Kadioglu A, Stover CM, Andrew PW, Schwaeble WJ. Ali YM, et al. Among authors: dudler t. PLoS Pathog. 2012;8(7):e1002793. doi: 10.1371/journal.ppat.1002793. Epub 2012 Jul 5. PLoS Pathog. 2012. PMID: 22792067 Free PMC article.
Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2.
Yaseen S, Demopulos G, Dudler T, Yabuki M, Wood CL, Cummings WJ, Tjoelker LW, Fujita T, Sacks S, Garred P, Andrew P, Sim RB, Lachmann PJ, Wallis R, Lynch N, Schwaeble WJ. Yaseen S, et al. Among authors: dudler t. FASEB J. 2017 May;31(5):2210-2219. doi: 10.1096/fj.201601306R. Epub 2017 Feb 10. FASEB J. 2017. PMID: 28188176
Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins.
Ali YM, Ferrari M, Lynch NJ, Yaseen S, Dudler T, Gragerov S, Demopulos G, Heeney JL, Schwaeble WJ. Ali YM, et al. Among authors: dudler t. Front Immunol. 2021 Jul 5;12:714511. doi: 10.3389/fimmu.2021.714511. eCollection 2021. Front Immunol. 2021. PMID: 34290717 Free PMC article.
27 results