Dudley DT - Search Results

1

Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.

Kinsey SG, Naidu PS, Cravatt BF, Dudley DT, Lichtman AH. Kinsey SG, et al. Among authors: dudley dt. Pharmacol Biochem Behav. 2011 Oct;99(4):718-25. doi: 10.1016/j.pbb.2011.06.022. Epub 2011 Jun 29. Pharmacol Biochem Behav. 2011. PMID: 21740924 Free PMC article.

2

Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.

Ahn K, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF. Ahn K, et al. Among authors: dudley dt. J Pharmacol Exp Ther. 2011 Jul;338(1):114-24. doi: 10.1124/jpet.111.180257. Epub 2011 Apr 19. J Pharmacol Exp Ther. 2011. PMID: 21505060 Free PMC article.

3

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.

Johnson DS, Stiff C, Lazerwith SE, Kesten SR, Fay LK, Morris M, Beidler D, Liimatta MB, Smith SE, Dudley DT, Sadagopan N, Bhattachar SN, Kesten SJ, Nomanbhoy TK, Cravatt BF, Ahn K. Johnson DS, et al. Among authors: dudley dt. ACS Med Chem Lett. 2011 Feb 10;2(2):91-96. doi: 10.1021/ml100190t. ACS Med Chem Lett. 2011. PMID: 21666860 Free PMC article.

4

Design and synthesis of phenethyl benzo[1,4]oxazine-3-ones as potent inhibitors of PI3Kinasegamma.

Lanni TB Jr, Greene KL, Kolz CN, Para KS, Visnick M, Mobley JL, Dudley DT, Baginski TJ, Liimatta MB. Lanni TB Jr, et al. Among authors: dudley dt. Bioorg Med Chem Lett. 2007 Feb 1;17(3):756-60. doi: 10.1016/j.bmcl.2006.10.080. Epub 2006 Oct 28. Bioorg Med Chem Lett. 2007. PMID: 17095227

5

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.

Barrett SD, Bridges AJ, Dudley DT, Saltiel AR, Fergus JH, Flamme CM, Delaney AM, Kaufman M, LePage S, Leopold WR, Przybranowski SA, Sebolt-Leopold J, Van Becelaere K, Doherty AM, Kennedy RM, Marston D, Howard WA Jr, Smith Y, Warmus JS, Tecle H. Barrett SD, et al. Among authors: dudley dt. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6501-4. doi: 10.1016/j.bmcl.2008.10.054. Epub 2008 Oct 15. Bioorg Med Chem Lett. 2008. PMID: 18952427

6

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo.

Sebolt-Leopold JS, Dudley DT, Herrera R, Van Becelaere K, Wiland A, Gowan RC, Tecle H, Barrett SD, Bridges A, Przybranowski S, Leopold WR, Saltiel AR. Sebolt-Leopold JS, et al. Among authors: dudley dt. Nat Med. 1999 Jul;5(7):810-6. doi: 10.1038/10533. Nat Med. 1999. PMID: 10395327

7

Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms.

Thiel MJ, Schaefer CJ, Lesch ME, Mobley JL, Dudley DT, Tecle H, Barrett SD, Schrier DJ, Flory CM. Thiel MJ, et al. Among authors: dudley dt. Arthritis Rheum. 2007 Oct;56(10):3347-57. doi: 10.1002/art.22869. Arthritis Rheum. 2007. PMID: 17907188 Free article.

8

Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352.

Delaney AM, Printen JA, Chen H, Fauman EB, Dudley DT. Delaney AM, et al. Among authors: dudley dt. Mol Cell Biol. 2002 Nov;22(21):7593-602. doi: 10.1128/MCB.22.21.7593-7602.2002. Mol Cell Biol. 2002. PMID: 12370306 Free PMC article.

9

Amylin increases cyclic AMP formation in L6 myocytes through calcitonin gene-related peptide receptors.

Zhu GC, Dudley DT, Saltiel AR. Zhu GC, et al. Among authors: dudley dt. Biochem Biophys Res Commun. 1991 Jun 14;177(2):771-6. doi: 10.1016/0006-291x(91)91855-7. Biochem Biophys Res Commun. 1991. PMID: 1646609 Free article.

10

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR. Dudley DT, et al. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7686-9. doi: 10.1073/pnas.92.17.7686. Proc Natl Acad Sci U S A. 1995. PMID: 7644477 Free PMC article.

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