Duff HJ - Search Results

1

Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study.

Perissinotti LL, De Biase PM, Guo J, Yang PC, Lee MC, Clancy CE, Duff HJ, Noskov SY. Perissinotti LL, et al. Among authors: duff hj. Front Physiol. 2018 Apr 12;9:207. doi: 10.3389/fphys.2018.00207. eCollection 2018. Front Physiol. 2018. PMID: 29706893 Free PMC article.

2

Selectivity filter modalities and rapid inactivation of the hERG1 channel.

Miranda WE, DeMarco KR, Guo J, Duff HJ, Vorobyov I, Clancy CE, Noskov SY. Miranda WE, et al. Among authors: duff hj. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2795-2804. doi: 10.1073/pnas.1909196117. Epub 2020 Jan 24. Proc Natl Acad Sci U S A. 2020. PMID: 31980532 Free PMC article.

3

Calmodulin kinase II accelerates L-type Ca2+ current recovery from inactivation and compensates for the direct inhibitory effect of [Ca2+]i in rat ventricular myocytes.

Guo J, Duff HJ. Guo J, et al. Among authors: duff hj. J Physiol. 2006 Jul 15;574(Pt 2):509-18. doi: 10.1113/jphysiol.2006.109199. Epub 2006 Apr 20. J Physiol. 2006. PMID: 16627565 Free PMC article.

4

Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function.

Lees-Miller JP, Subbotina JO, Guo J, Yarov-Yarovoy V, Noskov SY, Duff HJ. Lees-Miller JP, et al. Among authors: duff hj. Biophys J. 2009 May 6;96(9):3600-10. doi: 10.1016/j.bpj.2009.01.028. Biophys J. 2009. PMID: 19413965 Free PMC article.

5

Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations.

Subbotina J, Yarov-Yarovoy V, Lees-Miller J, Durdagi S, Guo J, Duff HJ, Noskov SY. Subbotina J, et al. Among authors: duff hj. Proteins. 2010 Nov 1;78(14):2922-34. doi: 10.1002/prot.22815. Proteins. 2010. PMID: 20740484 Free PMC article.

6

Combined receptor and ligand-based approach to the universal pharmacophore model development for studies of drug blockade to the hERG1 pore domain.

Durdagi S, Duff HJ, Noskov SY. Durdagi S, et al. Among authors: duff hj. J Chem Inf Model. 2011 Feb 28;51(2):463-74. doi: 10.1021/ci100409y. Epub 2011 Jan 11. J Chem Inf Model. 2011. PMID: 21241063

7

Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643.

Durdagi S, Guo J, Lees-Miller JP, Noskov SY, Duff HJ. Durdagi S, et al. Among authors: duff hj. J Pharmacol Exp Ther. 2012 Aug;342(2):441-52. doi: 10.1124/jpet.111.189159. Epub 2012 May 9. J Pharmacol Exp Ther. 2012. PMID: 22573844

8

Modeling of open, closed, and open-inactivated states of the hERG1 channel: structural mechanisms of the state-dependent drug binding.

Durdagi S, Deshpande S, Duff HJ, Noskov SY. Durdagi S, et al. Among authors: duff hj. J Chem Inf Model. 2012 Oct 22;52(10):2760-74. doi: 10.1021/ci300353u. Epub 2012 Oct 2. J Chem Inf Model. 2012. PMID: 22989185

9

Structure driven design of novel human ether-a-go-go-related-gene channel (hERG1) activators.

Guo J, Durdagi S, Changalov M, Perissinotti LL, Hargreaves JM, Back TG, Noskov SY, Duff HJ. Guo J, et al. Among authors: duff hj. PLoS One. 2014 Sep 5;9(9):e105553. doi: 10.1371/journal.pone.0105553. eCollection 2014. PLoS One. 2014. PMID: 25191697 Free PMC article.

10

NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.

Guo J, Cheng YM, Lees-Miller JP, Perissinotti LL, Claydon TW, Hull CM, Thouta S, Roach DE, Durdagi S, Noskov SY, Duff HJ. Guo J, et al. Among authors: duff hj. Biophys J. 2015 Mar 24;108(6):1400-1413. doi: 10.1016/j.bpj.2014.12.055. Biophys J. 2015. PMID: 25809253 Free PMC article.

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