Duignan DB - Search Results

1

Quantitative expression profile of hepatobiliary transporters in sandwich cultured rat and human hepatocytes.

Li N, Bi YA, Duignan DB, Lai Y. Li N, et al. Among authors: duignan db. Mol Pharm. 2009 Jul-Aug;6(4):1180-9. doi: 10.1021/mp900044x. Mol Pharm. 2009. PMID: 19545175

2

Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites.

Wang WW, Khetani SR, Krzyzewski S, Duignan DB, Obach RS. Wang WW, et al. Among authors: duignan db. Drug Metab Dispos. 2010 Oct;38(10):1900-5. doi: 10.1124/dmd.110.034876. Epub 2010 Jul 1. Drug Metab Dispos. 2010. PMID: 20595376

3

Characterization of digoxin uptake in sandwich-cultured human hepatocytes.

Kimoto E, Chupka J, Xiao Y, Bi YA, Duignan DB. Kimoto E, et al. Among authors: duignan db. Drug Metab Dispos. 2011 Jan;39(1):47-53. doi: 10.1124/dmd.110.034298. Epub 2010 Oct 6. Drug Metab Dispos. 2011. PMID: 20926619

4

Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.

Feng B, Xu JJ, Bi YA, Mireles R, Davidson R, Duignan DB, Campbell S, Kostrubsky VE, Dunn MC, Smith AR, Wang HF. Feng B, et al. Among authors: duignan db. Toxicol Sci. 2009 Apr;108(2):492-500. doi: 10.1093/toxsci/kfp033. Epub 2009 Feb 17. Toxicol Sci. 2009. PMID: 19223659

5

Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor (+)-2-[4-({[2-(benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid in rat and human.

Kalgutkar AS, Feng B, Nguyen HT, Frederick KS, Campbell SD, Hatch HL, Bi YA, Kazolias DC, Davidson RE, Mireles RJ, Duignan DB, Choo EF, Zhao SX. Kalgutkar AS, et al. Among authors: duignan db. Drug Metab Dispos. 2007 Nov;35(11):2111-8. doi: 10.1124/dmd.107.016162. Epub 2007 Aug 8. Drug Metab Dispos. 2007. PMID: 17686907

6

A 96-well efflux assay to identify ABCG2 substrates using a stably transfected MDCK II cell line.

Xiao Y, Davidson R, Smith A, Pereira D, Zhao S, Soglia J, Gebhard D, de Morais S, Duignan DB. Xiao Y, et al. Among authors: duignan db. Mol Pharm. 2006 Jan-Feb;3(1):45-54. doi: 10.1021/mp050088t. Mol Pharm. 2006. PMID: 16686368

7

Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport.

Bi YA, Kazolias D, Duignan DB. Bi YA, et al. Among authors: duignan db. Drug Metab Dispos. 2006 Sep;34(9):1658-65. doi: 10.1124/dmd.105.009118. Epub 2006 Jun 16. Drug Metab Dispos. 2006. PMID: 16782767

8

pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1.

Varma MV, Rotter CJ, Chupka J, Whalen KM, Duignan DB, Feng B, Litchfield J, Goosen TC, El-Kattan AF. Varma MV, et al. Among authors: duignan db. Mol Pharm. 2011 Aug 1;8(4):1303-13. doi: 10.1021/mp200103h. Epub 2011 Jul 11. Mol Pharm. 2011. PMID: 21710988

9

Understanding the clinical pharmacokinetics of a GABAA partial agonist by application of in vitro tools.

Sawant AD, Miller EL, Duignan DB, Brodfuehrer J, Winter SM, Nelson FR, Kamel A, Obach RS, Vaz AD. Sawant AD, et al. Among authors: duignan db. Xenobiotica. 2010 Jul;40(7):476-84. doi: 10.3109/00498254.2010.481057. Xenobiotica. 2010. PMID: 20429841

10

The development and validation of a computational model to predict rat liver microsomal clearance.

Chang C, Duignan DB, Johnson KD, Lee PH, Cowan GS, Gifford EM, Stankovic CJ, Lepsy CS, Stoner CL. Chang C, et al. Among authors: duignan db. J Pharm Sci. 2009 Aug;98(8):2857-67. doi: 10.1002/jps.21651. J Pharm Sci. 2009. PMID: 19116953

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