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Receptor autoradiography as mean to explore the possible functional relevance of neuropeptides: focus on new agonists and antagonists to study natriuretic peptides, neuropeptide Y and calcitonin gene-related peptides.
Dumont Y, Chabot JG, Quirion R. Dumont Y, et al. Peptides. 2004 Mar;25(3):365-91. doi: 10.1016/j.peptides.2004.01.013. Peptides. 2004. PMID: 15134861 Review.
Natriuretic peptide (NP), neuropeptide Y (NPY) and calcitonin (CT) peptide families are widely distributed in the peripheral and central nervous system and induced multiple biological effects by activating plasma membrane receptor proteins. ...Five NPY receptors have been …
Natriuretic peptide (NP), neuropeptide Y (NPY) and calcitonin (CT) peptide families are widely distributed in the peripheral and cent …
Adrenomedullin receptor binding sites in rat brain and peripheral tissues.
Juaneda C, Dumont Y, Chabot JG, Fournier A, Quirion R. Juaneda C, et al. Eur J Pharmacol. 2003 Aug 8;474(2-3):165-74. doi: 10.1016/s0014-2999(03)02042-9. Eur J Pharmacol. 2003. PMID: 12921858
BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist.
Dumont Y, Cadieux A, Doods H, Pheng LH, Abounader R, Hamel E, Jacques D, Regoli D, Quirion R. Dumont Y, et al. Br J Pharmacol. 2000 Mar;129(6):1075-88. doi: 10.1038/sj.bjp.0703162. Br J Pharmacol. 2000. PMID: 10725255 Free PMC article.
BIIE0246, a newly synthesized non-peptide neuropeptide Y (NPY) Y(2) receptor antagonist, was able to compete with high affinity (8 to 15 nM) for specific [(125)I]PYY(3 - 36) binding sites in HEK293 cells transfected with the rat Y(2) receptor cDNA, and in rat …
BIIE0246, a newly synthesized non-peptide neuropeptide Y (NPY) Y(2) receptor antagonist, was able to compete with high affinit …
The dog saphenous vein: a sensitive and selective preparation for the Y2 receptor of neuropeptide Y.
Pheng LH, Fournier A, Dumont Y, Quirion R, Regoli D. Pheng LH, et al. Eur J Pharmacol. 1997 May 30;327(2-3):163-7. doi: 10.1016/s0014-2999(97)89656-2. Eur J Pharmacol. 1997. PMID: 9200555
The dose-response curves obtained with neuropeptide Y, peptide YY and with C-terminal fragments such as neuropeptide Y-(2-26), neuropeptide Y-(13-36) and peptide YY-(3-36) have similar slopes and maxima. ...The neuropeptide Y Y1 receptor-selective agon …
The dose-response curves obtained with neuropeptide Y, peptide YY and with C-terminal fragments such as neuropeptide Y-(2-26), …
Conformational and biological studies of neuropeptide Y analogs containing structural alterations.
Fournier A, Gagnon D, Quirion R, Cadieux A, Dumont Y, Pheng LH, St-Pierre S. Fournier A, et al. Mol Pharmacol. 1994 Jan;45(1):93-101. Mol Pharmacol. 1994. PMID: 8302286
We evaluated the alpha-helix content, the biological activities and the affinities of a series of neuropeptide Y (NPY) analogs containing structural alterations, mainly in the central portion of the molecule for which a putative alpha-helix arrangement has been proposed. . …
We evaluated the alpha-helix content, the biological activities and the affinities of a series of neuropeptide Y (NPY) analogs contai …
Comparative affinities and antagonistic potencies of various human calcitonin gene-related peptide fragments on calcitonin gene-related peptide receptors in brain and periphery.
Mimeault M, Fournier A, Dumont Y, St-Pierre S, Quirion R. Mimeault M, et al. J Pharmacol Exp Ther. 1991 Sep;258(3):1084-90. J Pharmacol Exp Ther. 1991. PMID: 1653835
Evaluation of truncated neuropeptide Y analogues with modifications of the tyrosine residue in position 1 on Y1, Y2 and Y3 receptor sub-types.
Dumont Y, Satoh H, Cadieux A, Taoudi-Benchekroun M, Pheng LH, St-Pierre S, Fournier A, Quirion R. Dumont Y, et al. Eur J Pharmacol. 1993 Jul 6;238(1):37-45. doi: 10.1016/0014-2999(93)90502-9. Eur J Pharmacol. 1993. PMID: 8405081
Substitutions of the tyrosine residue in position 1 of truncated neuropeptide Y (N-terminal fragment 1-4 linked to C-terminal fragment 18-36 by the epsilon-aminocaproic acid) produced analogues that compete for specific [125I]polypeptide YY (PYY) binding in the frontoparie …
Substitutions of the tyrosine residue in position 1 of truncated neuropeptide Y (N-terminal fragment 1-4 linked to C-terminal fragmen …
Peptide YY derivatives as selective neuropeptide Y/peptide YY Y1 and Y2 agonists devoided of activity for the Y3 receptor sub-type.
Dumont Y, Cadieux A, Pheng LH, Fournier A, St-Pierre S, Quirion R. Dumont Y, et al. Brain Res Mol Brain Res. 1994 Oct;26(1-2):320-4. doi: 10.1016/0169-328x(94)90105-8. Brain Res Mol Brain Res. 1994. PMID: 7854062
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