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Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling.
Betts JC, Lukey PT, Robb LC, McAdam RA, Duncan K. Betts JC, et al. Among authors: duncan k. Mol Microbiol. 2002 Feb;43(3):717-31. doi: 10.1046/j.1365-2958.2002.02779.x. Mol Microbiol. 2002. PMID: 11929527
HemZ is essential for heme biosynthesis in Mycobacterium tuberculosis.
Parish T, Schaeffer M, Roberts G, Duncan K. Parish T, et al. Among authors: duncan k. Tuberculosis (Edinb). 2005 May;85(3):197-204. doi: 10.1016/j.tube.2005.01.002. Tuberculosis (Edinb). 2005. PMID: 15850757
Differential gene expression identifies novel markers of CD4+ and CD8+ T cell activation following stimulation by Mycobacterium tuberculosis.
Cliff JM, Andrade IN, Mistry R, Clayton CL, Lennon MG, Lewis AP, Duncan K, Lukey PT, Dockrell HM. Cliff JM, et al. Among authors: duncan k. J Immunol. 2004 Jul 1;173(1):485-93. doi: 10.4049/jimmunol.173.1.485. J Immunol. 2004. PMID: 15210809
Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response.
Cliff JM, Lee JS, Constantinou N, Cho JE, Clark TG, Ronacher K, King EC, Lukey PT, Duncan K, Van Helden PD, Walzl G, Dockrell HM. Cliff JM, et al. Among authors: duncan k. J Infect Dis. 2013 Jan 1;207(1):18-29. doi: 10.1093/infdis/jis499. Epub 2012 Aug 7. J Infect Dis. 2013. PMID: 22872737
Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth.
Wall MD, Oshin M, Chung GA, Parkhouse T, Gore A, Herreros E, Cox B, Duncan K, Evans B, Everett M, Mendoza A. Wall MD, et al. Among authors: duncan k. Bioorg Med Chem Lett. 2007 May 15;17(10):2740-4. doi: 10.1016/j.bmcl.2007.02.078. Epub 2007 Mar 3. Bioorg Med Chem Lett. 2007. PMID: 17418567
Gene-expression patterns in whole blood identify subjects at risk for recurrent tuberculosis.
Mistry R, Cliff JM, Clayton CL, Beyers N, Mohamed YS, Wilson PA, Dockrell HM, Wallace DM, van Helden PD, Duncan K, Lukey PT. Mistry R, et al. Among authors: duncan k. J Infect Dis. 2007 Feb 1;195(3):357-65. doi: 10.1086/510397. Epub 2006 Dec 21. J Infect Dis. 2007. PMID: 17205474
Prospects for new antitubercular drugs.
Duncan K, Barry CE 3rd. Duncan K, et al. Curr Opin Microbiol. 2004 Oct;7(5):460-5. doi: 10.1016/j.mib.2004.08.011. Curr Opin Microbiol. 2004. PMID: 15451500 Review.
Signature gene expression profiles discriminate between isoniazid-, thiolactomycin-, and triclosan-treated Mycobacterium tuberculosis.
Betts JC, McLaren A, Lennon MG, Kelly FM, Lukey PT, Blakemore SJ, Duncan K. Betts JC, et al. Among authors: duncan k. Antimicrob Agents Chemother. 2003 Sep;47(9):2903-13. doi: 10.1128/aac.47.9.2903-2913.2003. Antimicrob Agents Chemother. 2003. PMID: 12936993 Free PMC article.
Progress in TB drug development and what is still needed.
Duncan K. Duncan K. Tuberculosis (Edinb). 2003;83(1-3):201-7. doi: 10.1016/s1472-9792(02)00076-8. Tuberculosis (Edinb). 2003. PMID: 12758212 Review.
Characterization of a Mycobacterium tuberculosis H37Rv transposon library reveals insertions in 351 ORFs and mutants with altered virulence.
McAdam RA, Quan S, Smith DA, Bardarov S, Betts JC, Cook FC, Hooker EU, Lewis AP, Woollard P, Everett MJ, Lukey PT, Bancroft GJ, Jacobs WR Jr, Duncan K. McAdam RA, et al. Among authors: duncan k. Microbiology (Reading). 2002 Oct;148(Pt 10):2975-2986. doi: 10.1099/00221287-148-10-2975. Microbiology (Reading). 2002. PMID: 12368431
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