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Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats.
Rock EM, Sticht MA, Duncan M, Stott C, Parker LA. Rock EM, et al. Br J Pharmacol. 2013 Oct;170(3):671-8. doi: 10.1111/bph.12322. Br J Pharmacol. 2013. PMID: 23902479 Free PMC article.
Neuromotor tolerability and behavioural characterisation of cannabidiolic acid, a phytocannabinoid with therapeutic potential for anticipatory nausea.
Brierley DI, Samuels J, Duncan M, Whalley BJ, Williams CM. Brierley DI, et al. Psychopharmacology (Berl). 2016 Jan;233(2):243-54. doi: 10.1007/s00213-015-4100-1. Epub 2015 Oct 6. Psychopharmacology (Berl). 2016. PMID: 26439367
Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats.
Brierley DI, Samuels J, Duncan M, Whalley BJ, Williams CM. Brierley DI, et al. Psychopharmacology (Berl). 2016 Oct;233(19-20):3603-13. doi: 10.1007/s00213-016-4397-4. Epub 2016 Aug 9. Psychopharmacology (Berl). 2016. PMID: 27503475 Free PMC article.
Cannabidivarin is anticonvulsant in mouse and rat.
Hill AJ, Mercier MS, Hill TD, Glyn SE, Jones NA, Yamasaki Y, Futamura T, Duncan M, Stott CG, Stephens GJ, Williams CM, Whalley BJ. Hill AJ, et al. Br J Pharmacol. 2012 Dec;167(8):1629-42. doi: 10.1111/j.1476-5381.2012.02207.x. Br J Pharmacol. 2012. PMID: 22970845 Free PMC article.
Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation.
Bolognini D, Rock EM, Cluny NL, Cascio MG, Limebeer CL, Duncan M, Stott CG, Javid FA, Parker LA, Pertwee RG. Bolognini D, et al. Br J Pharmacol. 2013 Mar;168(6):1456-70. doi: 10.1111/bph.12043. Br J Pharmacol. 2013. PMID: 23121618 Free PMC article.
Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism.
Hill TD, Cascio MG, Romano B, Duncan M, Pertwee RG, Williams CM, Whalley BJ, Hill AJ. Hill TD, et al. Br J Pharmacol. 2013 Oct;170(3):679-92. doi: 10.1111/bph.12321. Br J Pharmacol. 2013. PMID: 23902406 Free PMC article.
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