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Daunomycin- and adriamycin-N-(2-hydroxypropyl)methacrylamide copolymer conjugates; toxicity reduction by improved drug-delivery.
Seymour LW, Duncan R, Kopecková P, Kopecek J. Seymour LW, et al. Among authors: duncan r. Cancer Treat Rev. 1987 Dec;14(3-4):319-27. doi: 10.1016/0305-7372(87)90024-7. Cancer Treat Rev. 1987. PMID: 3326668 Review. No abstract available.
Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro.
Rihova B, Bilej M, Vetvicka V, Ulbrich K, Strohalm J, Kopecek J, Duncan R. Rihova B, et al. Among authors: duncan r. Biomaterials. 1989 Jul;10(5):335-42. doi: 10.1016/0142-9612(89)90075-6. Biomaterials. 1989. PMID: 2765631
The pharmacokinetics of polymer-bound adriamycin.
Seymour LW, Ulbrich K, Strohalm J, Kopecek J, Duncan R. Seymour LW, et al. Among authors: duncan r. Biochem Pharmacol. 1990 Mar 15;39(6):1125-31. doi: 10.1016/0006-2952(90)90293-t. Biochem Pharmacol. 1990. PMID: 2322298
Polymeric drug-carriers containing doxorubicin and melanocyte-stimulating hormone: in vitro and in vivo evaluation against murine melanoma.
O'Hare KB, Duncan R, Strohalm J, Ulbrich K, Kopeckova P. O'Hare KB, et al. Among authors: duncan r. J Drug Target. 1993;1(3):217-29. doi: 10.3109/10611869308996079. J Drug Target. 1993. PMID: 8069563
Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.
Seymour LW, Duncan R, Strohalm J, Kopecek J. Seymour LW, et al. Among authors: duncan r. J Biomed Mater Res. 1987 Nov;21(11):1341-58. doi: 10.1002/jbm.820211106. J Biomed Mater Res. 1987. PMID: 3680316
Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia.
Duncan R, Kopecková P, Strohalm J, Hume IC, Lloyd JB, Kopecek J. Duncan R, et al. Br J Cancer. 1988 Feb;57(2):147-56. doi: 10.1038/bjc.1988.31. Br J Cancer. 1988. PMID: 3358905 Free PMC article.
Evaluation of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates as targetable drug carriers. 1. Binding, pinocytic uptake and intracellular distribution of transferrin and anti-transferrin receptor antibody conjugates.
Flanagan PA, Kopecková P, Kopecek J, Duncan R. Flanagan PA, et al. Among authors: duncan r. Biochim Biophys Acta. 1989 Oct 13;993(1):83-91. doi: 10.1016/0304-4165(89)90146-3. Biochim Biophys Acta. 1989. PMID: 2804126
Effect of galactose on interaction of N-(2-hydroxypropyl)methacrylamide copolymers with hepatoma cells in culture: preliminary application to an anticancer agent, daunomycin.
O'Hare KB, Hume IC, Scarlett L, Chytrý V, Kopecková P, Kopecek J, Duncan R. O'Hare KB, et al. Among authors: duncan r. Hepatology. 1989 Aug;10(2):207-14. doi: 10.1002/hep.1840100215. Hepatology. 1989. PMID: 2545589
Drug-polymer conjugates: potential for improved chemotherapy.
Duncan R. Duncan R. Anticancer Drugs. 1992 Jun;3(3):175-210. doi: 10.1097/00001813-199206000-00001. Anticancer Drugs. 1992. PMID: 1525399 Review.
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