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Page 1
Screening technologies for ion channel drug discovery.
Terstappen GC, Roncarati R, Dunlop J, Peri R. Terstappen GC, et al. Among authors: dunlop j. Future Med Chem. 2010 May;2(5):715-30. doi: 10.4155/fmc.10.180. Future Med Chem. 2010. PMID: 21426199 Review.
Ion channel screening.
Dunlop J, Bowlby M, Peri R, Tawa G, LaRocque J, Soloveva V, Morin J. Dunlop J, et al. Comb Chem High Throughput Screen. 2008 Aug;11(7):514-22. doi: 10.2174/138620708785204117. Comb Chem High Throughput Screen. 2008. PMID: 18694388 Review.
Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).
Ghiron C, Haydar SN, Aschmies S, Bothmann H, Castaldo C, Cocconcelli G, Comery TA, Di L, Dunlop J, Lock T, Kramer A, Kowal D, Jow F, Grauer S, Harrison B, La Rosa S, Maccari L, Marquis KL, Micco I, Nencini A, Quinn J, Robichaud AJ, Roncarati R, Scali C, Terstappen GC, Turlizzi E, Valacchi M, Varrone M, Zanaletti R, Zanelli U. Ghiron C, et al. Among authors: dunlop j. J Med Chem. 2010 Jun 10;53(11):4379-89. doi: 10.1021/jm901692q. J Med Chem. 2010. PMID: 20465311
Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders.
Roncarati R, Scali C, Comery TA, Grauer SM, Aschmi S, Bothmann H, Jow B, Kowal D, Gianfriddo M, Kelley C, Zanelli U, Ghiron C, Haydar S, Dunlop J, Terstappen GC. Roncarati R, et al. Among authors: dunlop j. J Pharmacol Exp Ther. 2009 May;329(2):459-68. doi: 10.1124/jpet.108.150094. Epub 2009 Feb 17. J Pharmacol Exp Ther. 2009. PMID: 19223665
In vitro screening strategies for nicotinic receptor ligands.
Dunlop J, Roncarati R, Jow B, Bothmann H, Lock T, Kowal D, Bowlby M, Terstappen GC. Dunlop J, et al. Biochem Pharmacol. 2007 Oct 15;74(8):1172-81. doi: 10.1016/j.bcp.2007.07.006. Epub 2007 Jul 10. Biochem Pharmacol. 2007. PMID: 17706607
Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625.
Marquis KL, Comery TA, Jow F, Navarra RL, Grauer SM, Pulicicchio C, Kelley C, Brennan JA, Roncarati R, Scali C, Haydar S, Ghiron C, Terstappen GC, Dunlop J. Marquis KL, et al. Among authors: dunlop j. Psychopharmacology (Berl). 2011 Dec;218(4):635-47. doi: 10.1007/s00213-011-2357-6. Epub 2011 Jun 4. Psychopharmacology (Berl). 2011. PMID: 21643676
640 results