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Modeling the clinical phenotype of BTK inhibition in the mature murine immune system.
Benson MJ, Rodriguez V, von Schack D, Keegan S, Cook TA, Edmonds J, Benoit S, Seth N, Du S, Messing D, Nickerson-Nutter CL, Dunussi-Joannopoulos K, Rankin AL, Ruzek M, Schnute ME, Douhan J 3rd. Benson MJ, et al. Among authors: dunussi joannopoulos k. J Immunol. 2014 Jul 1;193(1):185-97. doi: 10.4049/jimmunol.1302570. Epub 2014 Jun 4. J Immunol. 2014. PMID: 24899507
Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis.
Rankin AL, Seth N, Keegan S, Andreyeva T, Cook TA, Edmonds J, Mathialagan N, Benson MJ, Syed J, Zhan Y, Benoit SE, Miyashiro JS, Wood N, Mohan S, Peeva E, Ramaiah SK, Messing D, Homer BL, Dunussi-Joannopoulos K, Nickerson-Nutter CL, Schnute ME, Douhan J 3rd. Rankin AL, et al. Among authors: dunussi joannopoulos k. J Immunol. 2013 Nov 1;191(9):4540-50. doi: 10.4049/jimmunol.1301553. Epub 2013 Sep 25. J Immunol. 2013. PMID: 24068666
Variants within STAT genes reveal association with anticitrullinated protein antibody-negative rheumatoid arthritis in 2 European populations.
Seddighzadeh M, Gonzalez A, Ding B, Ferreiro-Iglesias A, Gomez-Reino JJ; Rheumatoid Arthritis Network and Coordinated Project; Klareskog L, Alfredsson L, Dunussi-Joannopoulos K, Clark JD, Padyukov L. Seddighzadeh M, et al. Among authors: dunussi joannopoulos k. J Rheumatol. 2012 Aug;39(8):1509-16. doi: 10.3899/jrheum.111284. Epub 2012 Jul 1. J Rheumatol. 2012. PMID: 22753649
IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.
Rankin AL, Guay H, Herber D, Bertino SA, Duzanski TA, Carrier Y, Keegan S, Senices M, Stedman N, Ryan M, Bloom L, Medley Q, Collins M, Nickerson-Nutter C, Craft J, Young D, Dunussi-Joannopoulos K. Rankin AL, et al. Among authors: dunussi joannopoulos k. J Immunol. 2012 Feb 15;188(4):1656-67. doi: 10.4049/jimmunol.1003871. Epub 2012 Jan 9. J Immunol. 2012. PMID: 22231702 Free PMC article.
IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice.
Van Belle AB, de Heusch M, Lemaire MM, Hendrickx E, Warnier G, Dunussi-Joannopoulos K, Fouser LA, Renauld JC, Dumoutier L. Van Belle AB, et al. Among authors: dunussi joannopoulos k. J Immunol. 2012 Jan 1;188(1):462-9. doi: 10.4049/jimmunol.1102224. Epub 2011 Nov 30. J Immunol. 2012. PMID: 22131335
Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis.
Kim KH, Maderna A, Schnute ME, Hegen M, Mohan S, Miyashiro J, Lin L, Li E, Keegan S, Lussier J, Wrocklage C, Nickerson-Nutter CL, Wittwer AJ, Soutter H, Caspers N, Han S, Kurumbail R, Dunussi-Joannopoulos K, Douhan J 3rd, Wissner A. Kim KH, et al. Among authors: dunussi joannopoulos k. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6258-63. doi: 10.1016/j.bmcl.2011.09.008. Epub 2011 Sep 10. Bioorg Med Chem Lett. 2011. PMID: 21958547
46 results