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Clostridium difficile: New Insights into the Evolution of the Pathogenicity Locus.
Monot M, Eckert C, Lemire A, Hamiot A, Dubois T, Tessier C, Dumoulard B, Hamel B, Petit A, Lalande V, Ma L, Bouchier C, Barbut F, Dupuy B. Monot M, et al. Sci Rep. 2015 Oct 8;5:15023. doi: 10.1038/srep15023. Sci Rep. 2015. PMID: 26446480 Free PMC article.
The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with three additional genes that have been implicated in regulation (tcdR and tcdC) and secretion (tc …
The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form …
Cpe1786/IscR of Clostridium perfringens represses expression of genes involved in Fe-S cluster biogenesis.
André G, Haudecoeur E, Courtois E, Monot M, Dupuy B, Rodionov DA, Martin-Verstraete I. André G, et al. Res Microbiol. 2017 May;168(4):345-355. doi: 10.1016/j.resmic.2016.03.002. Epub 2016 Mar 26. Res Microbiol. 2017. PMID: 27020244
Clostridium difficile toxin expression is inhibited by the novel regulator TcdC.
Matamouros S, England P, Dupuy B. Matamouros S, et al. Mol Microbiol. 2007 Jun;64(5):1274-88. doi: 10.1111/j.1365-2958.2007.05739.x. Mol Microbiol. 2007. PMID: 17542920
CcpA-mediated repression of Clostridium difficile toxin gene expression.
Antunes A, Martin-Verstraete I, Dupuy B. Antunes A, et al. Mol Microbiol. 2011 Feb;79(4):882-99. doi: 10.1111/j.1365-2958.2010.07495.x. Epub 2010 Dec 28. Mol Microbiol. 2011. PMID: 21299645
BotR/A and TetR are alternative RNA polymerase sigma factors controlling the expression of the neurotoxin and associated protein genes in Clostridium botulinum type A and Clostridium tetani.
Raffestin S, Dupuy B, Marvaud JC, Popoff MR. Raffestin S, et al. Mol Microbiol. 2005 Jan;55(1):235-49. doi: 10.1111/j.1365-2958.2004.04377.x. Mol Microbiol. 2005. PMID: 15612931
BotR/A and TetR are seemingly related to a new subgroup of the sigma70 family that includes TcdR and UviA, which, respectively, regulate production of toxins A and B in C. difficile and bacteriocin in C. perfringens. ...
BotR/A and TetR are seemingly related to a new subgroup of the sigma70 family that includes TcdR and UviA, which, respectively, regulate pro …
Secretion of Clostridium difficile toxins A and B requires the holin-like protein TcdE.
Govind R, Dupuy B. Govind R, et al. PLoS Pathog. 2012;8(6):e1002727. doi: 10.1371/journal.ppat.1002727. Epub 2012 Jun 7. PLoS Pathog. 2012. PMID: 22685398 Free PMC article.
C. difficile toxins A and B have no export signature and their secretion is not explainable by cell lysis, suggesting that they might be secreted by an unusual mechanism. ...
C. difficile toxins A and B have no export signature and their secretion is not explainable by cell lysis, suggesting that they might …
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