Durden DL - Search Results

1

Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis.

Andrews FH, Singh AR, Joshi S, Smith CA, Morales GA, Garlich JR, Durden DL, Kutateladze TG. Andrews FH, et al. Among authors: durden dl. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1072-E1080. doi: 10.1073/pnas.1613091114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137841 Free PMC article.

2

A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1α and HIF2α stability and tumor growth, angiogenesis, and metastasis.

Joshi S, Singh AR, Zulcic M, Durden DL. Joshi S, et al. Among authors: durden dl. Mol Cancer Res. 2014 Oct;12(10):1520-31. doi: 10.1158/1541-7786.MCR-13-0682. Epub 2014 Aug 7. Mol Cancer Res. 2014. PMID: 25103499

3

Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma.

Joshi S, Singh AR, Durden DL. Joshi S, et al. Among authors: durden dl. Cancer Chemother Pharmacol. 2015 Mar;75(3):595-608. doi: 10.1007/s00280-014-2639-x. Epub 2015 Jan 13. Cancer Chemother Pharmacol. 2015. PMID: 25578041

4

PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma.

Singh AR, Joshi S, Zulcic M, Alcaraz M, Garlich JR, Morales GA, Cho YJ, Bao L, Levy ML, Newbury R, Malicki D, Messer K, Crawford J, Durden DL. Singh AR, et al. Among authors: durden dl. PLoS One. 2016 Mar 3;11(3):e0150836. doi: 10.1371/journal.pone.0150836. eCollection 2016. PLoS One. 2016. PMID: 26938241 Free PMC article.

5

Single Agent and Synergistic Activity of the "First-in-Class" Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma.

Singh AR, Joshi S, Burgoyne AM, Sicklick JK, Ikeda S, Kono Y, Garlich JR, Morales GA, Durden DL. Singh AR, et al. Among authors: durden dl. Mol Cancer Ther. 2016 Nov;15(11):2553-2562. doi: 10.1158/1535-7163.MCT-15-0976. Epub 2016 Aug 5. Mol Cancer Ther. 2016. PMID: 27496136 Free PMC article.

6

SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer.

Joshi S, Singh AR, Liu KX, Pham TV, Zulcic M, Skola D, Chun HB, Glass CK, Morales GA, Garlich JR, Durden DL. Joshi S, et al. Among authors: durden dl. Mol Cancer Ther. 2019 Jun;18(6):1036-1044. doi: 10.1158/1535-7163.MCT-18-1206. Epub 2019 Apr 24. Mol Cancer Ther. 2019. PMID: 31018997 Free PMC article.

7

Macrophage Syk-PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression.

Joshi S, Liu KX, Zulcic M, Singh AR, Skola D, Glass CK, Sanders PD, Sharabi AB, Pham TV, Tamayo P, Shiang D, Dinh HQ, Hedrick CC, Morales GA, Garlich JR, Durden DL. Joshi S, et al. Among authors: durden dl. Mol Cancer Ther. 2020 Mar;19(3):755-764. doi: 10.1158/1535-7163.MCT-19-0947. Epub 2020 Jan 23. Mol Cancer Ther. 2020. PMID: 31974273 Free PMC article.

8

Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets.

Vann KR, Pal D, Morales GA, Burgoyne AM, Durden DL, Kutateladze TG. Vann KR, et al. Among authors: durden dl. Sci Rep. 2020 Jul 21;10(1):12027. doi: 10.1038/s41598-020-68964-6. Sci Rep. 2020. PMID: 32694708 Free PMC article.

9

Augmented Antitumor Activity for Novel Dual PI3K/BDR4 Inhibitors, SF2523 and SF1126 in Ewing Sarcoma.

Goldin AN, Singh A, Joshi S, Jamieson C, Durden DL. Goldin AN, et al. Among authors: durden dl. J Pediatr Hematol Oncol. 2021 Apr 1;43(3):e304-e311. doi: 10.1097/MPH.0000000000002054. J Pediatr Hematol Oncol. 2021. PMID: 33480647

10

Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo.

Joshi S, Singh AR, Zulcic M, Bao L, Messer K, Ideker T, Dutkowski J, Durden DL. Joshi S, et al. Among authors: durden dl. PLoS One. 2014 Apr 25;9(4):e95893. doi: 10.1371/journal.pone.0095893. eCollection 2014. PLoS One. 2014. PMID: 24770346 Free PMC article.

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