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1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo.
Chow EC, Durk MR, Cummins CL, Pang KS. Chow EC, et al. Among authors: durk mr. J Pharmacol Exp Ther. 2011 Jun;337(3):846-59. doi: 10.1124/jpet.111.179101. Epub 2011 Mar 18. J Pharmacol Exp Ther. 2011. PMID: 21421739
Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.
Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS. Chow EC, et al. Among authors: durk mr. Gastroenterology. 2014 Apr;146(4):1048-59. doi: 10.1053/j.gastro.2013.12.027. Epub 2013 Dec 21. Gastroenterology. 2014. PMID: 24365583
Comparative effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(-/-) mice.
Chow EC, Durk MR, Maeng HJ, Pang KS. Chow EC, et al. Among authors: durk mr. Biopharm Drug Dispos. 2013 Oct;34(7):402-16. doi: 10.1002/bdd.1856. Epub 2013 Sep 16. Biopharm Drug Dispos. 2013. PMID: 23897575
1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.
Durk MR, Chan GN, Campos CR, Peart JC, Chow EC, Lee E, Cannon RE, Bendayan R, Miller DS, Pang KS. Durk MR, et al. J Neurochem. 2012 Dec;123(6):944-53. doi: 10.1111/jnc.12041. Epub 2012 Nov 1. J Neurochem. 2012. PMID: 23035695 Free PMC article.
Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion.
Pang KS, Durk MR. Pang KS, et al. Among authors: durk mr. J Pharmacokinet Pharmacodyn. 2010 Dec;37(6):591-615. doi: 10.1007/s10928-010-9185-x. Epub 2010 Dec 14. J Pharmacokinet Pharmacodyn. 2010. PMID: 21153869 Review.
1α,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac.
Maeng HJ, Durk MR, Chow EC, Ghoneim R, Pang KS. Maeng HJ, et al. Among authors: durk mr. Biopharm Drug Dispos. 2011 Mar;32(2):112-25. doi: 10.1002/bdd.742. Epub 2011 Jan 14. Biopharm Drug Dispos. 2011. PMID: 21341280
1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease.
Durk MR, Han K, Chow EC, Ahrens R, Henderson JT, Fraser PE, Pang KS. Durk MR, et al. J Neurosci. 2014 May 21;34(21):7091-101. doi: 10.1523/JNEUROSCI.2711-13.2014. J Neurosci. 2014. PMID: 24849345 Free PMC article.
Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats.
Durk MR, Fan J, Sun H, Yang Y, Pang H, Pang KS, de Lannoy IA. Durk MR, et al. Pharm Res. 2015 Mar;32(3):1128-40. doi: 10.1007/s11095-014-1524-y. Epub 2014 Oct 16. Pharm Res. 2015. PMID: 25319098
Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats.
Durk MR, Deshmukh G, Valle N, Ding X, Liederer BM, Liu X. Durk MR, et al. Drug Metab Dispos. 2018 Jul;46(7):964-969. doi: 10.1124/dmd.118.080697. Epub 2018 Apr 26. Drug Metab Dispos. 2018. PMID: 29700231
Quantitative Intracerebral Microdialysis Studies to Determine Unbound Extracellular Fluid Drug Concentrations in Discrete Areas of the Brain.
Durk MR. Durk MR. Curr Protoc Pharmacol. 2018 Mar;80(1):7.18.1-7.18.19. doi: 10.1002/cpph.38. Curr Protoc Pharmacol. 2018. PMID: 30040217
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