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Extrarenal production of calcitriol.
Dusso A, Brown A, Slatopolsky E. Dusso A, et al. Semin Nephrol. 1994 Mar;14(2):144-55. Semin Nephrol. 1994. PMID: 8177981 Review.
The simultaneous expression of vitamin D receptors, constitutive 1 alpha-hydroxylase, and inducible 24-hydroxylase activity in the same cell or in cells of the nearby environment suggests that they constitute a means for an in situ regulation of the response to vitamin D. …
The simultaneous expression of vitamin D receptors, constitutive 1 alpha-hydroxylase, and inducible 24-hydroxylase activity in the same cell …
Defective renal maintenance of the vitamin D endocrine system impairs vitamin D renoprotection: a downward spiral in kidney disease.
Dusso AS, Tokumoto M. Dusso AS, et al. Kidney Int. 2011 Apr;79(7):715-29. doi: 10.1038/ki.2010.543. Epub 2011 Jan 26. Kidney Int. 2011. PMID: 21270766 Review.
In kidney disease, the progressive loss of renal capacity to produce calcitriol, the vitamin D hormone, is a key contributor to elevations in parathyroid hormone (PTH) and mineral and skeletal disorders predisposing to renal and cardiovascular damage, ectopic calcification …
In kidney disease, the progressive loss of renal capacity to produce calcitriol, the vitamin D hormone, is a key contributor to eleva …
Activator protein 2alpha mediates parathyroid TGF-alpha self-induction in secondary hyperparathyroidism.
Arcidiacono MV, Cozzolino M, Spiegel N, Tokumoto M, Yang J, Lu Y, Sato T, Lomonte C, Basile C, Slatopolsky E, Dusso AS. Arcidiacono MV, et al. Among authors: dusso as. J Am Soc Nephrol. 2008 Oct;19(10):1919-28. doi: 10.1681/ASN.2007111216. Epub 2008 Jun 25. J Am Soc Nephrol. 2008. PMID: 18579641 Free PMC article.
In secondary hyperparathyroidism, enhanced expression of TGF-alpha in the parathyroid leads to its own upregulation, generating a feed-forward loop for TGF-alpha activation of its receptor, EGFR receptor (EGFR), which promotes parathyroid hyperplasia. ...Furthermore, the i …
In secondary hyperparathyroidism, enhanced expression of TGF-alpha in the parathyroid leads to its own upregulation, generating a fee …
EGFR activation increases parathyroid hyperplasia and calcitriol resistance in kidney disease.
Arcidiacono MV, Sato T, Alvarez-Hernandez D, Yang J, Tokumoto M, Gonzalez-Suarez I, Lu Y, Tominaga Y, Cannata-Andia J, Slatopolsky E, Dusso AS. Arcidiacono MV, et al. Among authors: dusso as. J Am Soc Nephrol. 2008 Feb;19(2):310-20. doi: 10.1681/ASN.2007040406. Epub 2008 Jan 23. J Am Soc Nephrol. 2008. PMID: 18216322 Free PMC article.
In a rat model of SH, activation of the EGF receptor (EGFR) by TGF-alpha is required for the development of parathyroid hyperplasia, but the relationship between EGFR activation and reduced VDR content is unknown. ...Increased TGF-alpha/EGFR activation induced the synthesi …
In a rat model of SH, activation of the EGF receptor (EGFR) by TGF-alpha is required for the development of parathyroid hyperplasia, …
A critical role for enhanced TGF-alpha and EGFR expression in the initiation of parathyroid hyperplasia in experimental kidney disease.
Cozzolino M, Lu Y, Sato T, Yang J, Suarez IG, Brancaccio D, Slatopolsky E, Dusso AS. Cozzolino M, et al. Among authors: dusso as. Am J Physiol Renal Physiol. 2005 Nov;289(5):F1096-102. doi: 10.1152/ajprenal.00167.2005. Epub 2005 Jul 5. Am J Physiol Renal Physiol. 2005. PMID: 15998841
Because enhanced coexpression of TGF-alpha and EGFR causes aggressive cellular growth, these studies utilized highly specific inhibitors of EGFR tyrosine kinase, a step mandatory for TGF-alpha-induced EGFR activation, to assess the contribution of growth signals from enhan …
Because enhanced coexpression of TGF-alpha and EGFR causes aggressive cellular growth, these studies utilized highly specific inhibitors of …
Vitamin D.
Dusso AS, Brown AJ, Slatopolsky E. Dusso AS, et al. Am J Physiol Renal Physiol. 2005 Jul;289(1):F8-28. doi: 10.1152/ajprenal.00336.2004. Am J Physiol Renal Physiol. 2005. PMID: 15951480 Review.
Vitamin D itself is a prohormone that is metabolically converted to the active metabolite, 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. ...This local production of 1,25(OH)(2)D(3) is dependent on circulating precursor levels, providing a potential explanation for the ass …
Vitamin D itself is a prohormone that is metabolically converted to the active metabolite, 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. .. …
[Renal failure and vitamin D].
Brown AJ, Dusso AS, Slatopolsky E. Brown AJ, et al. Among authors: dusso as. Clin Calcium. 2002 Jun;12(6):711-23. Clin Calcium. 2002. PMID: 15775356 Japanese.
Animal studies have demonstrated that OCT and 19-nor D(2) have a wider therapeutic window for suppression of parathyroid hormone (PTH) because of their lower calcemic activities of OCT has been attributed to its rapid clearance which prevents sustained effects on intestina …
Animal studies have demonstrated that OCT and 19-nor D(2) have a wider therapeutic window for suppression of parathyroid hormone (PTH …
Vitamin D receptor and analogs.
Dusso AS, Thadhani R, Slatopolsky E. Dusso AS, et al. Semin Nephrol. 2004 Jan;24(1):10-6. doi: 10.1053/j.semnephrol.2003.08.018. Semin Nephrol. 2004. PMID: 14730505 Review.
Calcitriol reduction of parathyroid hyperplasia and serum PTH levels demands a functional vitamin D receptor (VDR). Although VDR is normal in CKD, parathyroid VDR content is reduced markedly. ...Although not all analog formulations are equally effective, they offer a
Calcitriol reduction of parathyroid hyperplasia and serum PTH levels demands a functional vitamin D receptor (VDR). Although VDR is n …
HIV-protease inhibitors impair vitamin D bioactivation to 1,25-dihydroxyvitamin D.
Cozzolino M, Vidal M, Arcidiacono MV, Tebas P, Yarasheski KE, Dusso AS. Cozzolino M, et al. Among authors: dusso as. AIDS. 2003 Mar 7;17(4):513-20. doi: 10.1097/00002030-200303070-00006. AIDS. 2003. PMID: 12598771
BACKGROUND: A high prevalence of bone demineralization occurs in people living with HIV/AIDS. The contribution of HIV itself and its treatment is still unclear. ...If PIs elicit a similar potency in inhibiting these critical steps for 1,25(OH) D homeostasis, defecti …
BACKGROUND: A high prevalence of bone demineralization occurs in people living with HIV/AIDS. The contribution of HIV itself and its …
The effects of sevelamer hydrochloride and calcium carbonate on kidney calcification in uremic rats.
Cozzolino M, Dusso AS, Liapis H, Finch J, Lu Y, Burke SK, Slatopolsky E. Cozzolino M, et al. Among authors: dusso as. J Am Soc Nephrol. 2002 Sep;13(9):2299-308. doi: 10.1097/01.asn.0000025782.24383.0d. J Am Soc Nephrol. 2002. PMID: 12191974

However, sevelamer caused a dramatic reduction of renal Ca deposition (29.8 +/- 8.6 micro g/g wet tissue) compared with both U-HP (175.5 +/- 45.7 micro g/g wet tissue, P < 0.01) and the U-HP+C (58.9 +/- 13.7 micro g/g wet tissue, P < 0.04). ...It is concluded that in

However, sevelamer caused a dramatic reduction of renal Ca deposition (29.8 +/- 8.6 micro g/g wet tissue) compared with both U-HP (17 …
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