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Bronchial aspirin challenge causes specific eicosanoid response in aspirin-sensitive asthmatics.
Szczeklik A, Sladek K, Dworski R, Nizankowska E, Soja J, Sheller J, Oates J. Szczeklik A, et al. Among authors: dworski r. Am J Respir Crit Care Med. 1996 Dec;154(6 Pt 1):1608-14. doi: 10.1164/ajrccm.154.6.8970343. Am J Respir Crit Care Med. 1996. PMID: 8970343
Prednisone increases PGH-synthase 2 in atopic humans in vivo.
Dworski RT, Funk CD, Oates JA, Sheller JR. Dworski RT, et al. Am J Respir Crit Care Med. 1997 Jan;155(1):351-7. doi: 10.1164/ajrccm.155.1.9001335. Am J Respir Crit Care Med. 1997. PMID: 9001335
Prostaglandin E(2) decreases allergen-stimulated release of prostaglandin D(2) in airways of subjects with asthma.
Hartert TV, Dworski RT, Mellen BG, Oates JA, Murray JJ, Sheller JR. Hartert TV, et al. Among authors: dworski rt. Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):637-40. doi: 10.1164/ajrccm.162.2.9904038. Am J Respir Crit Care Med. 2000. PMID: 10934099 Clinical Trial.
Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway hyperresponsiveness in allergic mice.
Peebles RS Jr, Dworski R, Collins RD, Jarzecka K, Mitchell DB, Graham BS, Sheller JR. Peebles RS Jr, et al. Among authors: dworski r. Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):676-81. doi: 10.1164/ajrccm.162.2.9911063. Am J Respir Crit Care Med. 2000. PMID: 10934105
Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress.
Dworski R, Murray JJ, Roberts LJ 2nd, Oates JA, Morrow JD, Fisher L, Sheller JR. Dworski R, et al. Am J Respir Crit Care Med. 1999 Dec;160(6):1947-51. doi: 10.1164/ajrccm.160.6.9903064. Am J Respir Crit Care Med. 1999. PMID: 10588611 Clinical Trial.
Allergen-stimulated release of mediators into sheep bronchoalveolar lavage fluid. Effect of cyclooxygenase inhibition.
Dworski R, Sheller JR, Wickersham NE, Oates JA, Brigham KL, Roberts LJ 2nd, Fitzgerald GA. Dworski R, et al. Am Rev Respir Dis. 1989 Jan;139(1):46-51. doi: 10.1164/ajrccm/139.1.46. Am Rev Respir Dis. 1989. PMID: 2492175
Allergen-stimulated release of thromboxane A2 and leukotriene E4 in humans. Effect of indomethacin.
Sladek K, Dworski R, Fitzgerald GA, Buitkus KL, Block FJ, Marney SR Jr, Sheller JR. Sladek K, et al. Among authors: dworski r. Am Rev Respir Dis. 1990 Jun;141(6):1441-5. doi: 10.1164/ajrccm/141.6.1441. Am Rev Respir Dis. 1990. PMID: 2161626 Clinical Trial.
Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma.
Brightling CE, Ward R, Woltmann G, Bradding P, Sheller JR, Dworski R, Pavord ID. Brightling CE, et al. Among authors: dworski r. Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):878-82. doi: 10.1164/ajrccm.162.3.9909064. Am J Respir Crit Care Med. 2000. PMID: 10988099
Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics.
Macfarlane AJ, Dworski R, Sheller JR, Pavord ID, Kay AB, Barnes NC. Macfarlane AJ, et al. Among authors: dworski r. Am J Respir Crit Care Med. 2000 May;161(5):1553-8. doi: 10.1164/ajrccm.161.5.9906068. Am J Respir Crit Care Med. 2000. PMID: 10806153

The percentage of eosinophils at baseline correlated with the concentration of cys LTs (r = 0.84, p < 0.001) but not prostanoid mediators. Allergen challenge produced a significant increase in the concentration of sputum cys LTs from 3. 45 ng/ml sputum to 11.95 ng/ml (p

The percentage of eosinophils at baseline correlated with the concentration of cys LTs (r = 0.84, p < 0.001) but not prostanoid me

Induced sputum eicosanoid concentrations in asthma.
Pavord ID, Ward R, Woltmann G, Wardlaw AJ, Sheller JR, Dworski R. Pavord ID, et al. Among authors: dworski r. Am J Respir Crit Care Med. 1999 Dec;160(6):1905-9. doi: 10.1164/ajrccm.160.6.9903114. Am J Respir Crit Care Med. 1999. PMID: 10588604
There were no significant differences in the concentrations of other eicosanoids between groups, although there was a negative correlation between the percentage sputum eosinophil count and sputum PGE(2) concentration (r = -0.48; p < 0.01) in subjects with asthma. ...
There were no significant differences in the concentrations of other eicosanoids between groups, although there was a negative correlation b …
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