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Nuclear factor-kappaB mediated inhibition of cytokine production by imidazoline scaffolds.
Kahlon DK, Lansdell TA, Fisk JS, Hupp CD, Friebe TL, Hovde S, Jones AD, Dyer RD, Henry RW, Tepe JJ. Kahlon DK, et al. Among authors: dyer rd. J Med Chem. 2009 Mar 12;52(5):1302-9. doi: 10.1021/jm8013162. J Med Chem. 2009. PMID: 19220017
Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.
Johnson AR, Pavlovsky AG, Ortwine DF, Prior F, Man CF, Bornemeier DA, Banotai CA, Mueller WT, McConnell P, Yan C, Baragi V, Lesch C, Roark WH, Wilson M, Datta K, Guzman R, Han HK, Dyer RD. Johnson AR, et al. Among authors: dyer rd. J Biol Chem. 2007 Sep 21;282(38):27781-91. doi: 10.1074/jbc.M703286200. Epub 2007 Jul 10. J Biol Chem. 2007. PMID: 17623656 Free article.
Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Li JJ, Nahra J, Johnson AR, Bunker A, O'Brien P, Yue WS, Ortwine DF, Man CF, Baragi V, Kilgore K, Dyer RD, Han HK. Li JJ, et al. Among authors: dyer rd. J Med Chem. 2008 Feb 28;51(4):835-41. doi: 10.1021/jm701274v. Epub 2008 Feb 6. J Med Chem. 2008. PMID: 18251495
The role of arachidonic acid in the secretion of the amyloid precursor protein (APP).
Emmerling MR, Dudley DT, Dyer RD, Carroll RT, Doyle PD, Davis RE. Emmerling MR, et al. Ann N Y Acad Sci. 1996 Jan 17;777:310-5. doi: 10.1111/j.1749-6632.1996.tb34438.x. Ann N Y Acad Sci. 1996. PMID: 8624105
Novel aspects of lipid mediators.
Dyer RD, Marshall LA. Dyer RD, et al. Agents Actions Suppl. 1993;41:173-5. Agents Actions Suppl. 1993. PMID: 8100386 No abstract available.
The pharmacologic effects of 5-[3,5-bis(1,1-dimethylethyl)-4- hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione, choline salt (CI-986), a novel inhibitor of arachidonic acid metabolism in models of inflammation, analgesia and gastric irritation.
Schrier DJ, Baragi VM, Connor DT, Dyer RD, Jordan JH, Imre KM, Lesch ME, Mullican MD, Okonkwo GC, Conroy MC. Schrier DJ, et al. Prostaglandins. 1994 Jan;47(1):17-30. doi: 10.1016/0090-6980(94)90071-x. Prostaglandins. 1994. PMID: 8140259
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