Dynamical models of tuberculosis and their applications.
Math Biosci Eng. 2004.
PMID: 20369977
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Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Lancet. 2025 Oct 18;406(10513):1873-1922. doi: 10.1016/S0140-6736(25)01637-X. Epub 2025 Oct 12.
Lancet. 2025.
PMID: 41092926
Free PMC article.
Data were analysed using previously established modelling approaches, such as disease modelling meta-regression version 2.1 (DisMod-MR 2.1) and comparative risk assessment methods. ...INTERPRETATION: Our findings underscore the complex and dynamic nature of g …
Data were analysed using previously established modelling approaches, such as disease modelling meta-regression version 2.1 (D …
Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023.
J Am Coll Cardiol. 2025 Dec 2;86(22):2167-2243. doi: 10.1016/j.jacc.2025.08.015. Epub 2025 Sep 24.
J Am Coll Cardiol. 2025.
PMID: 40990886
Free article.
METHODS: The Global Burden of Disease (GBD) 2023 study, a multinational collaborative research study, quantified burden due to 375 diseases including CVD burden and identified drivers of change from 1990 to 2023 using all available data and statistical models. GBD 2023 est …
METHODS: The Global Burden of Disease (GBD) 2023 study, a multinational collaborative research study, quantified burden due to 375 diseases …
Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Lancet. 2025 Oct 18;406(10513):1811-1872. doi: 10.1016/S0140-6736(25)01917-8. Epub 2025 Oct 12.
Lancet. 2025.
PMID: 41092928
Free PMC article.
METHODS: GBD 2023 produced estimates for 292 causes of death disaggregated by age-sex-location-year in 204 countries and territories and 660 subnational locations for each year from 1990 until 2023. We used a modelling tool developed for GBD, the Cause of Death Ensemble …
METHODS: GBD 2023 produced estimates for 292 causes of death disaggregated by age-sex-location-year in 204 countries and territories and 660 …
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution.
Cell. 2025 Nov 13;188(23):6554-6571.e21. doi: 10.1016/j.cell.2025.08.008. Epub 2025 Aug 28.
Cell. 2025.
PMID: 40882628
Free article.
We demonstrated the robust performance of Stereo-seq V2 on clinical FFPE samples using triple-negative breast cancer (TNBC) sections and identified tumor-specific alternative splicing events. In a Mycobacterium tuberculosis (Mtb)-infected mouse model, we monitored g …
We demonstrated the robust performance of Stereo-seq V2 on clinical FFPE samples using triple-negative breast cancer (TNBC) sections and ide …
Dynamical models of tuberculosis and their applications.
Math Biosci Eng. 2004 Sep;1(2):361-404. doi: 10.3934/mbe.2004.1.361.
Math Biosci Eng. 2004.
PMID: 20369977
Free article.
The reemergence of tuberculosis (TB) from the 1980s to the early 1990s instigated extensive researches on the mechanisms behind the transmission dynamics of TB epidemics. ...Most recently developed models not only pay attention to simulations but also take ca …
The reemergence of tuberculosis (TB) from the 1980s to the early 1990s instigated extensive researches on the mechanisms behind the t …
Development and Analysis of Multiscale Models for Tuberculosis: From Molecules to Populations.
bioRxiv [Preprint]. 2023 Nov 15:2023.11.13.566861. doi: 10.1101/2023.11.13.566861.
bioRxiv. 2023.
PMID: 38014103
Free PMC article.
Preprint.
We review multiscale modeling approaches for complex, interconnected biological systems and discuss critical steps involved in building, analyzing, and applying such models within the discipline of model credibility. ...We also offer several promising future …
We review multiscale modeling approaches for complex, interconnected biological systems and discuss critical steps involved in buildi …
Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023.
Lancet. 2025 Oct 18;406(10513):1731-1810. doi: 10.1016/S0140-6736(25)01330-3. Epub 2025 Oct 12.
Lancet. 2025.
PMID: 41092927
Free PMC article.
This study-part of the latest GBD release, GBD 2023-aims to provide new and updated estimates of all-cause mortality and life expectancy for 1950 to 2023 using a novel statistical model that accounts for complex correlation structures in demographic data across age and tim …
This study-part of the latest GBD release, GBD 2023-aims to provide new and updated estimates of all-cause mortality and life expectancy for …
Global, regional, and national burden of breast cancer among females, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023.
Lancet Oncol. 2026 Mar;27(3):302-326. doi: 10.1016/S1470-2045(25)00730-2.
Lancet Oncol. 2026.
PMID: 41785894
Mortality estimates were generated using GBD Cause of Death Ensemble models, leveraging data from population-based cancer registration systems, vital registration systems, and verbal autopsies. ...Prevalence was calculated by combining incidence and modelled surviva …
Mortality estimates were generated using GBD Cause of Death Ensemble models, leveraging data from population-based cancer registratio …
Dynamic, spatial models of parasite transmission in wildlife: Their structure, applications and remaining challenges.
J Anim Ecol. 2018 May;87(3):559-580. doi: 10.1111/1365-2656.12761. Epub 2017 Oct 22.
J Anim Ecol. 2018.
PMID: 28944450
Review.
Individual differences in contact rate can arise from host, group and landscape heterogeneity and can result in different patterns of spatial spread for diseases in wildlife populations with concomitant implications for disease control in wildlife of conservation concern, livesto …
Individual differences in contact rate can arise from host, group and landscape heterogeneity and can result in different patterns of spatia …
Mechanistic Modeling of Mycobacterium tuberculosis Infection in Murine Models for Drug and Vaccine Efficacy Studies.
Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01727-19. doi: 10.1128/AAC.01727-19. Print 2020 Feb 21.
Antimicrob Agents Chemother. 2020.
PMID: 31907182
Free PMC article.
Tuberculosis (TB) drug, regimen, and vaccine development rely heavily on preclinical animal experiments, and quantification of bacterial and immune response dynamics is essential for understanding drug and vaccine efficacy. ...These findings demonstrate the utility …
Tuberculosis (TB) drug, regimen, and vaccine development rely heavily on preclinical animal experiments, and quantification of bacter …
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